Abstract:Objective To observe the weight loss of elderly depression patients, and to explore the factors influencing weight loss in elderly depression patients, so as to guide future weight intervention for elderly depression patients. Methods One hundred and ten elderly depression patients treated in Department of Gerontology, Mental Health Center, Shanghai Jiaotong University School of Medicine from January 2018 to December 2019 were prospectively selected. According to article 16 of HAMD-24 version, the weight loss was assessed and divided into weight loss group (weight loss of at least 0.5 kg within one week) and no weight loss group, and a self-made general information questionnaire was used to collect patient data. The influencing factors of weight loss in elderly patients with depression were analyzed by single-factor and multi-factor analysis. Results Among 110 elderly patients with depression, 46 cases lost weight, with an incidence of 41.82%. After a single logistic regression analysis and a multiple regression model were established, the results of multivariate analysis showed that anxiety-type depression, diabetes, high level of CRP, high level of IL-6 were the influencing factors of weight loss in elderly depression patients (OR = 11.528, 9.135, 5.141, 2.809, P < 0.05). Conclusion The incidence of weight loss in elderly patients with depression is high, which may be affected by factors such as anxiety-type depression, diabetes, and high levels of inflammatory factors. The clinic should pay attention to the early intervention of patients with the above risk factors.
黄静文 魏燕燕▲ 刘艳. 老年抑郁症患者体重降低的影响因素分析[J]. 中国医药导报, 2021, 18(2): 114-117.
HUANG Jingwen WEI Yanyan▲ LIU Yan. Analysis of influencing factors of weight loss in elderly patients with depression. 中国医药导报, 2021, 18(2): 114-117.
[1] Ma J,Rosas LG,Lv N,et al. Effect of integrated behavioral weight loss treatment and problem-solving therapy on body mass index and depressive symptoms among patients with obesity and depression:the RAINBOW randomized clinical trial [J]. JAMA,2019,321(9):869-879.
[2] Koopman M,El Aidy S,MIDtrauma consortium. Depressed gut? The microbiota-diet-inflammation trialogue in depression [J]. Curr Opin Psychiatry,2017,30(5):369-377.
[3] 陈媛媛,孙国珍,马潇然,等.慢性心力衰竭患者焦虑、抑郁与营养、睡眠质量状况及其相关性[J].现代临床护理,2017,16(10):12-16.
[4] Ahrén B,Atkin SL,Charpentier G,et al. Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials [J]. Diabetes Obes Metab,2018, 20(9):2210-2219.
[5] 孔宪焜,肖巧玲,李娟.老年抑郁症状相关因素的城乡比较[J].中国心理卫生杂志,2018,32(8):648-655.
[6] 陆益花,姜赟,沈毅.分位数回归分析冠心病患者中体重指数对抑郁的影响[J].中国卫生统计,2017,34(5):745-748.
[7] Obeid S,Abi Elias Hallit C,Haddad C,et al. Validation of the Hamilton depression rating scale (HDRS) and sociodemographic factors associated with Lebanese depressed patients [J]. Encephale,2018,44(5):397-402.
[8] 朱建立,张红星,顾丽华,等.抑郁症与肠道菌群相关性研究进展[J].国际精神病学杂志,2019,46(4):594-596, 600.
[9] 刘欣艺,乔晓霞,金雅茹,等.营养不良在社区老年人抑郁和衰弱之间的中介作用[J].中国老年学杂志,2019,39(18):4592-4595.
[10] 彭环,高玲玲.老年抑郁症患者日常活动能力现状及影响因素分析[J].中国实用护理杂志,2018,34(35):2758-2763.
[11] Perna S,Rondanelli M,Spadaccini D,et al. Are the therapeutic strategies in anorexia of ageing effective on nutritional status? A systematic review with meta-analysis [J]. J Hum Nutr Diet,2019,32(1):128-138.
[12] 高会莹,程秀丽,江美娜,等.老年住院患者抑郁症状与衰弱状况关系的研究[J].中华老年医学杂志,2019,38(6):631-634.
[13] 冯婷婷,张洪艳,张会杰,等.焦虑性抑郁症患者皮质醇节律紊乱及影响因素[J].中华行为医学与脑科学杂志,2019,28(6):499-504.
[14] 蒲虹杉.老年相关疾病与营养不良[J].肠外与肠内营养,2013,20(2):123-125,128.
[15] Chabowski M,Polański J,Jankowska-Polańska B,et al. Is nutritional status associated with the level of anxiety,depression and pain in patients with lung cancer? [J]. J Thorac Dis,2018,10(4):2303-2310.
[16] 陈媛媛,孙国珍,马潇然,等.慢性心力衰竭患者焦虑、抑郁与营养、睡眠质量状况及其相关性[J].现代临床护理,2017,16(10):12-16.
[17] 杨德爽,陈琪,陈光耀,等.抑郁症与神经-免疫-内分泌网的关系以及归脾汤的治疗作用[J].河南中医,2017, 37(5):800-802.
[18] B?觍descu SV,T?觍taru C,Kobylinska L,et al. The association between diabetes mellitus and depression [J]. J Med Life,2016,9(2):120-125.
[19] 罗怡欣,黄燕林,李浩宇,等.老年糖尿病肾病患者营养状况与焦虑、抑郁水平及认知功能的相关性研究[J].中华现代护理杂志,2017,23(10):1345-1348.
[20] Wolever TM. Nutrition and diabetes [J]. Can J Diabetes,2016,40(4):277.
[21] 王秋梅,刘晓红,孙晓红,等.社区居住的老年糖尿病患者的营养状态评估[J].中华老年多器官疾病杂志,2019, 18(8):569-572.
[22] 陈国忠,黄毅,陈宏斌,等.慢性阻塞性肺疾病的系统性炎症反应与营养不良相关性分析[J].中国医师杂志,2012, 14(1):64-66.
[23] 任克军,王青,胡顺金,等.微炎症状态对腹膜透析患者营养状况的影响[J].实用医学杂志,2015,31(3):427-429.
[24] 黄梅,俸桃,周桃梅,等.糖尿病肾病患者微炎症状态与营养不良的相关性研究[J].河北医学,2017,23(1):85-88.
[25] White JP,Baltcalvisk A,Puppa MJ,et al. Muscle oxidative capacity during IL-6 dependent cancer caehexia [J]. Am J Physiol Regul Integr Comp Physiol,2011,300(2):R201-R211.