Study on the the effects of recombinant human natriuretic peptide on ventricular remodeling and cardiac function after PCI for acute antetheca myocardial infarction
CHEN Hua LIU Xin▲
Emergency Department, Chinese PLA General Hospital, Beijing 100853, China
Abstract： Objective To study the effects of recombinant human natriuretic peptide (rhBNP) on ventricular remodeling and cardiac function after PCI for acute antetheca myocardial infarction (AMI). Methods The data of 80 patients with AMI in Chinese PLA General Hospital from January 2016 to January 2017 were retrospectively analyzed and divided into rhBNP group and the control group, according to different treatment, with 40 cases in each group. The control group was treated with routine PCI therapy, while the rhBNP group was treated with rhBNP intraoperative and postoperative PCI on the basis of the control group treatment. The systolic function, ventricular remodeling and plasma BNP and myocardial enzyme creatine kinase isoenzyme (CK-MB) levels and adverse reactions in two groups were observed. Results After operation, the levels of LVEF, LVPER in the both groups were on the rise, while the levels of LVTPER, LVESVI, LVEDVI, LVMI were in decline, with statistically significant difference (P < 0.05). Six months after operation, the levels of LVEF, LVPER in the rhBNP group were higher than those in the control group, while the level of LVTPER was lower than that in the control group, with statistically significant difference (P < 0.05). Besides, the levels of LVESVI, LVEDVI, LVMI in the rhBNP group were lower than those in the control group after operation (P < 0.05). Twenty-four hours after operation, the level of BNP in the rhBNP group and the levels of CK-MB in the both groups were higher than those before operation, then the level of BNP in the control group seventy-two hours after operation was higher than that before operation (P < 0.05). Conclusion rhBNP can be used to improve the left ventricular remodeling and cardiac function in patients with AMI, which has a obvious and safe effect.
陈骅 刘昕▲. 重组人脑利钠肽对急性前壁心梗急诊经皮冠状动脉介入术后心室重塑和心功能的影响[J]. 中国医药导报, 2018, 15(2): 58-61.
CHEN Hua LIU Xin▲. Study on the the effects of recombinant human natriuretic peptide on ventricular remodeling and cardiac function after PCI for acute antetheca myocardial infarction. 中国医药导报, 2018, 15(2): 58-61.
[1] Tran DT，Welsh RC，Ohinmaa A，et al. Quality of acute myocardial infarction care in canada：a 10-year review of 30-day in-hospital mortality and 30-day hospital readmission [J]. Can J Cardiol，2017，33（10）：1319-1326.
[2] Treskes RW，van Winden LA，van Keulen N，et al. Using smart technology to improve outcomes in myocardial infarction patients：rationale and design of a protocol for a randomized controlled trial，the box [J]. JMIR Res Protoc，2017，6（9）：e186.
[3] Sanaani A，Yandrapalli S，Jolly G，et al. Correlation between electrocardiographic changes and coronary findings in patients with acute myocardial infarction and single-vessel disease [J]. Ann Transl Med，2017，5（17）：347.
[4] Jneid H，Addison D，Bhatt DL，et al. 2017 AHA/ACC clinical performance and quality measures for adults with st-elevation and non-st-elevation myocardial infarction：a report of the American College of Cardiology/American Heart Association task force on performance measures [J]. Circ Cardiovasc Qual Outcomes，2017，10（10）：e000 032.
[5] Mccullough PA. Clinical applications of B-type natriuretic peptide levels in the care of cardiovascular patients [J]. Minerva Cardioangiol，2014，52（1）：479-489.
[6] 中华医学会心血管病学分会，介入心脏病学组，血栓防治专业委员会，等.中国经皮冠状动脉介入治疗指南（2016）[J].中华心血管病杂志，2016，44（5）：382-400.
[7] Meinel FG，Wichmann JL，Schoepf UJ，et al. Global quantification of left ventricular myocardial perfusion at dynamic CT imaging：prognostic value [J]. J Cardiovasc Comput Tomogr，2017，11（1）：16-24.
[8] Pabisiak A，Bromboszcz J，Kmiec S，et al. Changes in the complete blood count and blood rheology in patients after myocardial infarction participating in the rehabilitation programme [J]. Clin Hemorheol Microcirc，2015，61（3）：541-547.
[9] Li YR，Tsai SS，Lin YS，et al. Moderate- to high-intensity statins for secondary prevention in patients with type 2 diabetes mellitus on dialysis after acute myocardial infarction [J]. Diabetol Metab Syndr，2017，19（9）：71.
[10] Ritschel V，Shetelig C，Seljeflot I，et al. Evaluation of circulating levels of CCN2/connective tissue growth factor in patients with ST-elevation myocardial infarction [J]. Sci Rep，2017，7（1）：11 945.
[11] Tanaka T，Nishigaki K，Minatoguchi S，et al. Mobilized muse cells after acute myocardial infarction predict cardiac function and remodeling in the chronic phase [J]. Circ J，2017，9（20）：101.
[12] Korhonen MJ，Robinson JG，Annis IE，et al. Adherence tradeoff to multiple preventive therapies and all-cause mortality after acute myocardial infarction [J]. J Am Coll Cardiol，2017，70（13）：1543-1554.
[13] Zhu CP，Li TP，Wang X，et al. The relationship between apnoea hypopnoea index and Gensini score in patients with acute myocardial infarction undergoing emergency primary percutaneous coronary intervention [J]. J Thorac Dis，2017，9（8）：2476-2483.
[14] Maiello M，Zito A，Carbonara S，et al. Left ventricular mass，geometry and function in diabetic patients affected by coronary artery disease [J]. J Diabetes Complications，2017，31（10）：1533-1537.
[15] Hall ME，Halinski JA，Skelton TN，et al. Left ventricular false tendons are associated with left ventricular dilation and impaired systolic and diastolic function [J]. Am J Med Sci，2017，354（3）：278-284.
[16] Cozzolino M，Galassi A，Pivari F，et al. The cardiovascular burden in end-stage renal disease [J]. Contrib Nephrol，2017，191（1）：44-57.
[17] 严静，姚麒，储慧民，等.老年人血浆脑钠肽水平与急性心肌梗死部位和预后的关系研究[J].中华老年医学杂志，2016，35（1）：13-15.
[18] 李世强，傅向华，代玉涵，等.早期应用重组人B型利钠肽对ST段抬高型心肌梗死患者急诊冠状动脉介入术后心肌梗死面积的影响[J].中华心血管病杂志，2015， 43（11）：954-959.
[19] 李科，王国兴.重组人脑利钠肽治疗急性心力衰竭的疗效评价及预后影响因素分析[J].临床和实验医学杂志，2016，15（16）：1646-1650.
[20] 陈学，龙静，韩朝辉，等.和肽素脑钠肽及高敏肌钙蛋白T在急性心肌梗死中的早期诊断价值[J].中国急救医学，2016，36（7）：634-638.
[21] 李晶玮，王鸿，杜凤和，等.急性冠脉综合征患者B型利钠肽与全球急性冠状动脉事件注册评分的相关性[J].中国医药导报，2017，14（20）：54-57.
[22] 李红，张海玲，张莹，等.血清心肌酶谱、肌钙蛋白Ⅰ、肌红蛋白与脑钠肽的联合检测对临床诊断急性心肌梗死的意义[J].标记免疫分析与临床，2017，24（2）：167-170.
2018, Vol. 15 
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