1.The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China;
2.Department of Mammary Gland, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Province, Guangzhou 510000, China
Abstract：Objective To explore the analysis of adverse reactions and medication safety of Compound Kushen Injection based on literature reports. Methods From January 1996 to February 2020, the published relevant literatures on adverse drug reaction (ADR) of Compound Kushen Injections were retrieved by computer from CNKI, Wanfang data and VIP. The statistical analysis mainly involved general data, medical history data, dosage regimen and ADR related situation. Results A total of 13 literatures were enrolled, including 76 cases. ADR caused by Compound Kushen Injection mostly occurred in people over 40 years old, and female (41 cases) was higher than male (35 cases). The occurrence of ADR may be related to daily administration dosage, menstruum, drug combination and other factors. The dangerous period of Compound Kushen Injection was 30 minutes after first infusion. The clinical manifestations of ADR could be involved in many systems, among which, gastrointestinal system and systemic damage were the main ones. Conclusion Clinical use of Compound Kushen Injection should be strictly in accordance with the instructions, attention should be paid to special groups. During the use of drugs, especially within 30 min of the first infusion, it is necessary to closely monitor patients to avoid the occurrence of serious ADR.
2020, Vol. 17 
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