RNA结合基序蛋白25在恶性肿瘤中的研究进展

摘要
图/表
参考文献(30)
相关文章 (15)

全文: PDF (578 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 RNA结合基序蛋白25（RBM25）属于RNA结合蛋白家族，其表达蛋白位于细胞核核斑点上，是一种剪切因子，参与基因的选择性剪切过程。近年来，RBM25对恶性肿瘤的影响引起了越来越多的学者关注。目前研究表明，RBM25表达量的高低与异常剪切对恶性肿瘤的发生、发展、转移及预后均有影响。本文就RBM25与急性髓系白血病、前列腺癌、人乳头瘤病毒阳性头颈部恶性肿瘤、乳腺癌、肺腺癌、骨肉瘤及结肠癌等多种恶性肿瘤的研究进展作一综述。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	黎旺红唐津天舒垠刘晨王瑞宾王伯庆

关键词 ： RNA结合基序蛋白25, 恶性肿瘤, 选择性剪切, 剪切因子

Abstract：RNA binding motif protein 25 (RBM25) belongs to the RNA-binding protein family. It’s expressed proteins, located in nuclear spots, are shear factors and participate in the selective shearing process of genes. In recent years, more and more scholars have paid attention to the effect of RBM25 on malignant tumors. Current studies have shown that the high and low expression level of RBM25 and abnormal shear have an impact on the occurrence, development, metastasis and prognosis of malignant tumors. This paper reviews the research progress of RBM25 in diverse malignant tumors, such as acute myeloid leukemia, prostate cancer, human papillomavirus positive head and neck malignancies, breast cancer, lung adenocarcinoma, osteosarcoma and colon cancer and so on.

Key words： RNA binding motif protein 25 Malignant tumor Selective splicing Shear factor

基金资助:新疆维吾尔自治区自然科学基金资助项目（201 5211C126）。

通讯作者: 王伯庆（1974-），男，博士，副教授，硕士生导师，主任医师；研究方向：肝细胞肝癌基础与临床相关研究。

作者简介: 黎旺红（1994-），男，新疆医科大学第三临床医学院2018级肿瘤学专业在读硕士研究生；研究方向：肝细胞肝癌相关研究。

引用本文:

黎旺红唐津天舒垠刘晨王瑞宾王伯庆. RNA结合基序蛋白25在恶性肿瘤中的研究进展[J]. 中国医药导报, 2020, 17(35): 53-56.
LI Wanghong TANG Jintian SHU Yin LIU Chen WANG Ruibin WANG Boqing. Research progress of RNA binding motif 25 in malignant tumors. 中国医药导报, 2020, 17(35): 53-56.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I35/53

[1] Scotti MM，Swanson MS. RNA mis-splicing in disease [J]. Nat Rev Genet，2016，17（1）：19-32.
[2] Blencowe BJ. The Relationship between Alternative Splicing and Proteomic Complexity[J]. Trends Biochem Sci，2017，42（6）：407-408.
[3] Xiping Z，Qingshan W，Shuai Z. A summary of relationships between alternative splicing and breast cancer [J]. Oncotarget，2017，8（31）：51986-51993.
[4] Baralle FE，Giudice J. Alternative splicing as a regulator of development and tissue identity [J]. Nat Rev Mol Cell Biol，2017，18（7）：437-451.
[5] McCracken S，Lambermon M，Blencowe BJ. SRm160 splicing coactivator promotes transcript 3’-end cleavage [J]. Mol Cell Biol，2002，22（1）：148-160.
[6] Yan C，Hang J，Wan R. Structure of a yeast spliceosome at 3.6-angstrom resolution [J]. Science，2015，349（6253）：1182-1191.
[7] Xiong HY，Alipanahi B，Lee LJ，et al. RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease [J]. Science，2015，347（6218）：1254806.
[8] Gómez Acuña LI，Fiszbein A，Alló M，et al. Connections between chromatin signatures and splicing [J]. Wiley Interdiscip Rev RNA，2013，4（1）：77-91.
[9] 刑永强，刘国庆，蔡碌. Pre-mRNA选择性剪接的调控及选择性剪接数据库[J].中国生物化学与分子生物学报，2016，32（1）：17-28.
[10] Carlson SM, Soulette CM, Yang Z，et al. RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation [J]. J Biol Chem，2017，292（32）：13381-13390.
[11] Pan Q，Shai O，Lee LJ，et al. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing [J]. Nat Genet，2008，40（12）：1413-1415.
[12] Danan-Gotthold M，Golan-Gerstl R，Eisenberg E，et al. Identification of recurrent regulated alternative splicing events across human solid tumors [J]. Nucleic Acids Res，2015，43（10）：5130-5144.
[13] Gao Z，Chen M，Tian X，et al. A novel human lncRNA SANT1 cis-regulates the expression of SLC47A2 by altering SFPQ/E2F1/HDAC1 binding to the promoter region in renal cell carcinoma [J]. RNA Biol，2019，16（7）：940-949.
[14] de Silva HC，Lin MZ，Phillips L，et al. IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer [J]. Cell Mol Life Sci，2019，76（10）：2015-2030.
[15] Takayama KI，Suzuki T，Fujimura T，et al. Dysregulation of spliceosome gene expression in advanced prostate cancer by RNA-binding protein PSF [J]. Proc Natl Acad Sci U S A，2017，114（39）：10461-10466.
[16] Radhakrishnan A，Nanjappa V，Raja R，et al. Dysregulation of splicing proteins in head and necksquamous cell carcinoma [J]. Cancer Biol，2016，17（2）：219-229.
[17] Climente-González H，Porta-Pardo E，Godzik A. The Functional Impact of Alternative Splicing in Cancer [J]. Cell Rep，2017，20（9）：2215-2226.
[18] Lukong KE，Chang KW，Khandjian EW，et al. RNA-binding proteins in human genetic disease [J]. Trends Genet，2008，24（8）：416-425.
[19] Lee MH，Schedl T. RNA-binding proteins [J]. WormBook，2006，18：1-13.
[20] Zhou A，Ou AC，Cho A，et al. Novel splicing factor RBM25 modulates Bcl-X pre-mRNA 5’ splice site selection [J]. Mol Cell Biol，2008，28（19）：5924-5936.
[21] Zhan X，Qian B，Cao F. An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses [J]. Nat Commun，2015，6：8139.
[22] Gao G，Xie A，Huang SC，et al. Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure [J]. Circulation，2011，124（10）：1124-1131.
[23] Ge Y，Schuster MB，Pundhir S，et al. The splicing factor RBM25 controls MYC activity in acute myeloid leukemia [J]. Nat Commun，2019，10（1）：172.
[24] Yang Z，Qu CB，Zhang Y，et al. Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway [J]. Oncogene，2019，38（14）：2516-2532.
[25] Cheng Y，Li L，Qin Z，et al. Identification of castration‐resistant prostate cancer-related hub genes using weighted gene co-expression network analysis [J]. J Cell Mol Med，2020，24（14）：8006-8017.
[26] Wu Y，Chen H，Chen Y，et al. HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif [J]. Aging（Albany NY），2019，11（8）：2430-2446.
[27] Zhang Y，Cai Q，Shu XO，et al. Whole-Exome Sequencing Identifies Novel Somatic Mutations in Chinese Breast Cancer Patients [J]. J Mol Genet Med，2015，9（4）：183.
[28] 韩学艳，李畅. RNA结合基序蛋白25在肺腺癌组织中的表达及与预后的关系[J].检验医学与临床，2018，15（20）：3069-3072.
[29] Huang WT，Liu AG，Cai KT，et al. Exploration and validation of downregulated microRNA-199a-3p， downstream messenger RNA targets and transcriptional regulation in osteosarcoma [J]. Am J Transl Res，2019，11（12）：7538-7554.
[30] Huang X，Liu J，Mo X，et al. Systematic profiling of alternative splicing events and splicing factors in left- and right-sided colon cancer [J]. Aging（Albany NY），2019， 11（19）：8270-8293.