Abstract：Objective To study the risk factors of cerebral microbleeds (CMBs) in patients with ischemic stroke and to analyze the relationship between serum cystatin C (CysC), neutrophil/lymphocyte ratio (NLR) and CMBs. Methods A total of 80 patients with ischemic stroke admitted to Wuhu NO.1 People’s Hospital, Anhui Province from January 2017 to February 2020 were selected and divided into CMBs group (33 cases) and non-CMBs group (47 cases) according to the occurrence of CMBs. The differences of baseline data and biochemical indexes were compared between the two groups. The risk factors of CMBs and predictive value of CysC and NLR for CMBs were analyzed. Results The age and hypertension history rate in CMBs group were significantly higher than non-CMBs group (all P ＜ 0.05). The fasting blood-glucose (FBG), NLR and CysC levels of the CMBs group were higher than those of the non-CMBs group (all P ＜ 0.05). High age, with history of hypertension, high NLR, and high CysC levels were all independent risk factors for CMBs (all P ＜ 0.05). The receiver operating characteristic (ROC) curve analysis for the prediction and diagnosis of CMBs showed that the theoretical threshold of NLR was 2.60, the sensitivity was 80.2%, the specificity was 73.9%, and the area under curve (AUC) was 0.727 (P ＜ 0.05). The theoretical threshold of serum CysC level was 1.19 mg/L, the sensitivity was 82.6%, the specificity was 71.8%, and the AUC was 0.758 (P ＜ 0.05). The combined application of the two indexes had higher diagnostic efficiency: the sensitivity was 84.2%, the specificity was 85.0%, and the AUC was 0.845 (P ＜ 0.05). Conclusion Elderly patients with ischemic stroke who have a history of hypertension, high serum CysC level, and high NLR may be at higher risk of CMBs. Serum CysC level and NLR can be used as sensitive indicators for CMBs occurrence.
2020, Vol. 17 
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