Abstract：Gastrointestinal endoscopy can clearly detect gastrointestinal lesions through endoscopyas well as treating some gastrointestinal lesions. However, the patients always feel discomfort during the operation, which would affect the operation of the doctors. Anesthesiologists can provide the patients with moderate sedation and analgesia, relieve the patients’ discomfort and thus reduce surgical associated complications by intravenous drug administration. While the application of Propofol is welcomed by endoscopy doctors and patients, the adverse reactions such as hypotension and respiratory depression should not be ignored. As a result, drug developers and manufacturers have been trying to find alternatives to Propofol sedation. The latest finding is Remimazolam, a new drug of benzodiazepines that exhibits promising superiority in faster metabolic rate. In addition, many protocols for drug combination applications, such as Propofol-Demetomidine and Propofol-Chloramine combination, can markedly improve drug safety without affecting sedation quality. In this paper, the newly developed sedative and analgesic drugs and new drug combination strategies to provide some references for the clinicians.
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