腺样体肥大患儿变态反应结果分析

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摘要目的分析腺样体肥大（AH）患儿中变态反应指标[嗜酸粒细胞（EOS）和血清过敏原筛查]的临床特点。方法回顾性分析2017年10月—2019年7月湖北省妇幼保健院耳鼻咽喉科收治的以AH作为第一诊断的住院患儿303例。根据是否伴有变应性鼻炎（AR）分为AH组215例和AH+AR组88例。所有患儿抽取外周血检验EOS百分比，并进行血清过敏原筛查。结果 AH+AR组中EOS、总IgE明显高于AH组，差异有统计学意义（P ＜ 0.05）。AH+AR组中变应原阳性率为29.04%，其中最常见的变应原为屋尘螨（81.82%）、粉尘螨（68.18%）、霉菌混合（17.05%）和链格孢（13.64%）。单一变应原阳性率为26.14%，两种变应原阳性率为60.23%，同一患儿变应原种类最多可达9种。结论变态反应可能是AH患儿的致病因素之一，AH患儿变应原主要以室内尘螨为主，阳性程度以轻中度多见。

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	许胜1 褚汉启2 管红霞1▲

关键词 ：腺样体肥大, 变应性鼻炎, 变态反应, 嗜酸粒细胞, 过敏原筛查

Abstract：Objective To analyze the clinical characteristics of allergy indicators (screening of Eosinophils [EOS] and serum allergens) in children with adenoid hypertrophy (AH). Methods A retrospective analysis of 303 inpatients admitted to Department of Otolaryngology at Maternal and Child Health Hospital of Hubei Province from October 2017 to July 2019 with AH as the first diagnosis. According to whether it was accompanied by allergic rhinitis (AR), it was divided into AH group (215 cases) and AH+AR group (88 cases). Peripheral blood was drawn from all children for EOS percentage and serum allergen screening. Results EOS and total IgE in AH+AR group were significantly higher than those in AH group (P < 0.05). The positive rate of allergens in AH+AR group was 29.04%, of which the most common allergens were house dust mite (81.82%), dust mite (68.18%), mold mixture (17.05%) and alternaria alternata (13.64%). The positive rate of a single allergen was 26.14%, and the positive rate of two allergens was 60.23%. There were up to nine types of allergens in the same child. Conclusion Allergic reaction may be one of the pathogenic factors in children with AH. The allergens in children with AH are mainly house dust mites, and the positive degree is more common in mild to moderate.

Key words： Adenoid hypertrophy Allergic rhinitis Allergic reaction Eosinophil Allergen screening

基金资助:国家自然科学基金资助项目（81771004）。

通讯作者: ▲通讯作者

引用本文:

许胜1 褚汉启2 管红霞1▲. 腺样体肥大患儿变态反应结果分析[J]. 中国医药导报, 2020, 17(32): 76-78,95.
XU Sheng1 CHU Hanqi2 GUAN Hongxia1▲. Analysis of allergic reaction in children with adenoid hypertrophy. 中国医药导报, 2020, 17(32): 76-78,95.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I32/76

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