Relationship between metabolic syndrome caused by Olanzapine and serum IL-6 level and cognitive function
LU Weihong1 WEN Wanjun2 WANG Weiping3 TANG Wei4 ZHANG Yi1 ZHANG Chen1▲
1.Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China;
2.Department of Psychiatry, Yuebei Third People′s Hospital, Guangdong Province, Shaoguan 512200, China;
3.Department of Psychiatry, Jinhua Second Hospital, Zhejiang Province, Jinhua 321016, China;
4.Department of Psychiatry, Wenzhou Kangning Hospital, Zhejiang Province, Wenzhou 325000, China
Abstract：Objective To explore the relationship between metabolic syndrome (MS) caused by Olanzapine and serum interleukin-6 (IL-6) levels and cognitive function. Methods From January 2015 to December 2017, a total of 242 cases who were treated with Schizophrenia for more than two years of single-drug use were recruited at Shanghai Mental Health Center of Shanghai Jiao Tong University School of Medicine, Yuebei Third People′s Hospital, Jinhua Second Hospital, and Wenzhou Kangning Hospital in Zhejiang Province. According to whether they were associated with MS, they were divided into 105 cases in MS group and 137 cases in non-MS group. The positive and negative symptom scale (PANSS) was used to assess the clinical symptoms of patients with schizophrenia, while the repeatable battery for the assessment of neuropsychological status (RBANS) was used to assess cognitive function, and the serum IL-6 levels were measured by enzyme-linked immunosorbent assay. Results There were highly statistically significant differences in the use time and dose of Olanzapine between the two groups (P ＜ 0.01). The score of PANSS negative symptoms in the MS group was higher than that in the non-MS group, and the difference was statistically significant (P ＜ 0.05). The RBANS immediate memory, attention, delayed memory and total scores of the MS group were lower than those of the non-MS group, and the differences were statistically significant (P ＜ 0.05). The level of serum IL-6 in the MS group was higher than that in the non-MS group, and the difference was statistically significant (P ＜ 0.05). The serum IL-6 levels of the patients were negatively correlated with the RBANS attention score (r = -0.16, P ＜ 0.05). Conclusion The increase of IL-6 caused by MS caused by Olanzapine may cause secondary cognitive impairment in patients with schizophrenia.
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2020, Vol. 17 
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