Research progress of CD4 T lymphocytes in the pathogenesis of post-stroke depression
ZHANG Linli1 SONG Jinggui2
1.Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University, He′nan Province, Weihui 453100, China;
2.Department of Neurology, the Second Affiliated Hospital of Xinxiang Medical University, He′nan Province, Xinxiang 453002, China
Abstract：The pathophysiological mechanism of post-stroke depression is unclear. Regarding its neurobiological alterations, available research evidence includes elevated monoamine system (especially serotonin) alterations, hypothalamic pituitary adrenal axis abnormalities, disruption of the prefrontal cortex circuit, alterations in neuroplasticity and glutamate neurotransmission, and excess pro-inflammatory cytokines. The immune inflammatory response may play an important role in the pathophysiological process of post-stroke depression, especially the imbalance of CD4 T lymphocytes and their related cytokines, which may damage the neuroplasticity of T lymphocytes and maintain the function of the nervous system, resulting in the imbalance of the regulation of the immune inflammatory response after stroke, affecting the synthesis of neurotransmitters and the release of metabolism, thus leading to depression.
张林丽1 宋景贵2. CD4 T淋巴细胞在脑卒中后抑郁发病机制中的研究进展[J]. 中国医药导报, 2020, 17(31): 62-65.
ZHANG Linli1 SONG Jinggui2. Research progress of CD4 T lymphocytes in the pathogenesis of post-stroke depression. 中国医药导报, 2020, 17(31): 62-65.
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2020, Vol. 17 
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