Correlation study between renal injury and humoral immunity in patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjogren′s syndrome
GUO Huijuan1 TIAN Bingchao2 TANG Jinyang3 LI Qi1
1.Department of Clinical Laboratory, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China;
2.the Fifth Hospital of Tangshan City, Hebei Province, Tangshan 063000, China;
3.Department of Rheumatology, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China
Abstract：Objective To explore the correlation between renal injury and humoral immune in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and primary Sjogren′s syndrome (pSS). Methods Eighty-three cases of RA as RA group, 40 cases of SLE as SLE group and 50 cases of pSS as pSS group treated in Department of Rheumatology, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine from March 2018 to November 2018. Another 50 healthy persons in the same period were selected as control group. Serum immunoglobulin (IgG, IgA), urinary β2-microglobulin (β2-MG), α1-microglobulin (α1-MG), microalbumin (mALB), creatinine (Cr) and ACR were detected. Pearson analysis was used to analyze the correlation between renal injury index and humoral immunity. Results The levels of serum IgG, IgA, urinary β2-MG and α1-MG in pSS group, SLE group and RA group were higher than those in control group (P < 0.05). Urine Cr of pSS group and RA group was lower than that of control group, and ACR was higher than that of control group (P < 0.05). There was no significant difference in urine mALB level among four groups (P > 0.05). Serum IgA, β2-MG and IgG were positively correlated in RA group (P < 0.05). Serum IgA, mALB, α1-MG, β2-MG were positively correlated with IgG in SLE group (P < 0.05). There was a positive correlation between serum IgA, β2-MG and IgG in pSS group (P < 0.05). Conclusion The immunological indexes of RA, SLE and pSS patients are significantly increased, which indicated that humoral immunity might be activated in different degrees, leading to immune dysfunction. The increase of renal injury index indicates that RA, SLE and pSS may have different degrees of renal injury. The positive correlation between renal injury index and immunologic index indicates that serum immunoglobulin (IgG, IGA) may participate in the pathological process of renal injury, which can provide certain reference value for clinical diagnosis and treatment of patients.
2020, Vol. 17 
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