Analysis on the effect of antiviral therapy and correlation with viral load in patients with HIV/HBV co-infection
HUANG Chengjun1 CHENG Shuquan1▲ TIAN Qun1 LIN Jun2
1.Department of Liver Disease, the Third People′s Hospital of Guilin, Guangxi Zhuang Autonomous Region, Guilin 541001, China;
2.Department of Liver Disease, Ganzhou Fifth People′s Hospital, Jiangxi Province, Ganzhou 341000, China
Abstract：Objective To investigate the effect of antiviral therapy and correlation with viral load in patients with human immuncodeficiency virus/hepatits B virus (HIV/HBV) co-infection. Methods From January 2017 to December 2018, 147 patients with HBV and HIV infection in the Department of Infectious Diseases of the Third People′s Hospital of Guilin, Guangxi Zhuang Autonomous Region were selected as the research subjects. According to the type of infection, the patients were divided into three groups: 49 cases in HBV group, 50 cases in HIV group, and 48 cases in HIV/HBV group. Prospective analysis was conducted to calculate the correlation between liver and kidney function indexes of three groups of patients before and after treatment with HIV ribonucleic acid (HIV-RNA) and HBV deoxyribonucleic acid (HBV-DNA). Results The levels of alanine aminotransferase (ALT), total bilirubin (TBil) and direct bilirubin (DBil) in the HBV group after 24 weeks of treatment were lower than those after 12 weeks, and the levels of ALT, TBil and DBil after 48 weeks of treatment were lower than those after 24 weeks of treatment, and the differences were statistically significant (all P ＜ 0.05). The levels of TBil and DBil in the HIV group after 12 and 24 weeks of treatment were higher than those before treatment, aspartate aminotrransferase (AST) levels after 24 weeks of treatment were lower than those before treatment, after 48 weeks of treatment, the levels of AST, TBil and DBil were lower than those after 24 weeks of treatment, and the differences were statistically significant (P ＜ 0.05). After 12 weeks of treatment, the DBil level in the HIV/HBV group was lower than that before treatment, after 24 weeks of treatment DBil level was lower than that after 12 weeks of treatment, and that after 48 weeks of treatment was lower than that after 24 weeks of treatment, and the differences were statistically significant (P ＜ 0.05). After 24 weeks of treatment, the HBV-DNA level of the HIV/HBV group was higher than that of the HBV group, and the difference was statistically significant (P ＜ 0.05). After 24 weeks and 48 weeks of treatment, the levels of HIV-RNA in the HIV/HBV group were higher than that in the HIV group, and the differences were statistically significant (P ＜ 0.05). Conclusion The antiviral therapy is effective in the recovery of liver function for those HIV/HBV co-infected, but it is still difficult to eliminate HIV and HBV.
黄成军1 程书权1▲ 田群1 林君2. HIV/HBV合并感染患者抗病毒治疗的效果及与病毒载量之间相关性分析[J]. 中国医药导报, 2020, 17(28): 28-31.
HUANG Chengjun1 CHENG Shuquan1▲ TIAN Qun1 LIN Jun2. Analysis on the effect of antiviral therapy and correlation with viral load in patients with HIV/HBV co-infection. 中国医药导报, 2020, 17(28): 28-31.
2020, Vol. 17 
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