Abstract：Objective To investigate the regulation effect of Glargine combined with Atorvastatin on vascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus. Methods A total of 100 patients with type 2 diabetes mellitus who treated in Ma′anshan People′s Hospital, Anhui Province from January 2017 to January 2019 were selected, they were divided into the control group (50 cases, Insulin Glargine treatment) and the observation group (50 cases, Insulin Glargine combined with Atorvastatin treatment) by random number table method. The blood glucose control, vascular endothelial function (carotid artery intima-media thickness [IMT], serum nitric oxide [NO], plasma endothelin [ET-1]), oxidative stress response (malondialdehyde [MDA], glutathione peroxidase [GSH-PX], superoxide dismutase [SOD]) were compared between the two groups. Results After 12 weeks of treatment, the blood glucose levels of the two groups before breakfast and 2 h after breakfast were decreased, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05); the levels of IMT, ET-1, and MDA in the two groups were decreased, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05); the levels of NO, GSH-PX and SOD in the two groups were increased, and the observation group was higher than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Insulin Glargine combined with Atorvastatin in treatment of patients with type 2 diabetes mellitus can improve vascular endothelial function and oxidative stress response, and promote the stability of disease.
陈萍 陈卫红. 甘精胰岛素联合阿托伐他汀对2型糖尿病患者血管内皮功能及氧化应激的影响[J]. 中国医药导报, 2020, 17(27): 82-85.
CHEN Ping CHEN Weihong. Effect of Insulin Glargine combined with Atorvastatin on vascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus. 中国医药导报, 2020, 17(27): 82-85.
2020, Vol. 17 
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