Abstract：Objective To investigate the phenotypic distribution of bronchial asthma airway inflammation, airway inflammation markers detection and correlation analysis of asthma control, so as to provide clinical treatment guidance for patients. Methods The diagnosis and treatment of 110 asthma patients who diagnosed in Cangzhou Central Hospital of Hebei Province from May 2016 to May 2019 were retrospectively analyzed. According to the asthma control level, they were divided into complete control group (20 cases), partial control group (41 cases) and uncontrolled group (49 cases). The phenotypic distribution of airway inflammation in three groups of patients with bronchial asthma were analyzed, markers of airway inflammation were detected and the correlation between asthma control level and airway inflammation markers (exhaled nitric oxide [FeNO], serum total immunoglobulin [IgE], sputum eosinophils, blood eosinophils) were analyzed by Pearson correlation analysis. Results There were no significant differences in phenotype distribution of airway inflammation among three groups (P > 0.05). There were no significant differences in markers of airway inflammation among three groups (P > 0.05). There were no correlation between bronchial asthma control level and sputum eosinophils, FeNO, blood eosinophils and serum total IgE (P > 0.05). Conclusion There is no significant correlation between asthma control level and airway inflammation markers, whether airway inflammation markers should be used to determine the control level of bronchial asthma still needs to be determined based on individual patient conditions and subsequent studies.
2020, Vol. 17 
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