Progress on individualized administration of Linezolid
LIU Dong1 KONG Lingti2 XU Haiyan1
1.Department of Pharmacy, the People′s Hospital of Nanchuan, Chongqing Medical University, Chongqing 408400, China;
2.Department of Pharmacy, the First Affiliated Hospital of Bengbu Medical College, Anhui Province, Bengbu 233004, China
Abstract：Due to Vancomycin resistance and adverse reactions, Linezolid has become increasingly important in the treatment of infections caused by Methicillin-Resistant Staphylococcus Aureus and other multi-resistant and pan-resistant bacteria. However, research on how Linezolid can be personalized medicine is still insufficient. Studies have shown that the pharmacokinetics of Linezolid are affected by various factors such as age, gender, weight, liver and kidney function, and genes, which can lead to individual differences in efficacy and adverse reactions. Many studies have confirmed the role of therapeutic drug monitoring in the individualized administration of linezolid, but its application value remains to be further confirmed. Pharmacokinetics/pharmacodynamics studies have shown that individualized dosing regimens should be designed based on the patient′s disease status and drug sensitivity results. Therefore, clinical pharmacists should use therapeutic drug monitoring and pharmacokinetics/pharmacodynamics actively participate in clinical treatment to improve the effectiveness and safety of Linezolid anti-infective treatment.
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2020, Vol. 17 
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