Breast cancer ultrasound SWE technical analysis and its correlation with ER, PR, Ki-67 expression and molecular typing
WANG Yan1 FANG Kaifeng1 YU Qiuyu1 SONG Rui2
1.Department of Ultrasound, Wanbei Coal and Electricity Group General Hospital, Anhui Province, Suzhou 234000, China;
2.Department of Pathology, Wanbei Coal and Electricity Group General Hospital, Anhui Province, Suzhou 234000, China
Abstract：Objective To explore the analysis results of breast cancer ultrasound shear wave elastography (SWE) technical analysis and its correlation with estrogen receptor (ER), progesterone receptor (PR), Ki-67 antigen expression and molecular typing. Methods From June 2017 and October 2019, 100 patients with pathologically confirmed breast cancer who admitted in Wanbei Coal and Electricity Group General Hospital of Anhui Province were selected as research objects. Before the treatment, routine examination and SWE examination were performed in order to obtain the results of SWE technical analysis of the patients′ lesions. Postoperatively, the tumor tissue grade, ER, PR, Ki-67 antigen expression level and molecular typing of all patients were observed and recorded, and the correlation between the results of SWE technical analysis before operation and the expression levels of ER, PR, Ki-67 antigen and molecular typing in postoperative patients were analyzed. Results The differences of tumor size, Ki-67 antigen expression, tissue grade and elastic maximum square root [Sqrt(Emax)], elastic maximum square root [Sqrt(Emean)] and elastic ratio number [Log(Eratio)] were statistically significant (P < 0.05). However, there were no significant differences between ER expression level, PR expression level, Human epidermal growth factor receptor-2 (HER-2) expression level, molecular typing and Sqrt（Emax）, Sqrt（Emean）, Log（Eratio）(P > 0.05). The tumor size and Ki-67 antigen expression were correlated with Sqrt(Emax) and Sqrt(Emean) (P < 0.05), but not with Log(Eratio) (P > 0.05). There were no correlation between tumor tissue grade and Sqrt(Emax), Sqrt(Emean) and Log(Eratio) (P > 0.05). Conclusion SWE elasticity parameter can reflect the biological characteristics of breast cancer to a certain extent. The larger the mass, the higher the SWE elasticity value, and the higher the expression of Ki-67.
王燕1 方开峰1 俞秋雨1 宋瑞2. 乳腺癌超声SWE技术分析及其与ER、PR、Ki-67表达和分子分型的相关性[J]. 中国医药导报, 2020, 17(26): 21-25.
WANG Yan1 FANG Kaifeng1 YU Qiuyu1 SONG Rui2. Breast cancer ultrasound SWE technical analysis and its correlation with ER, PR, Ki-67 expression and molecular typing. 中国医药导报, 2020, 17(26): 21-25.
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2020, Vol. 17 
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