Study on ACTN3 gene polymorphism related to the difference of athletic ability in Northern HanZú and MongguZú population
WU Jian1 GAO Yuxue2 YANG Pengxiang3 GUO Xianghua2
1.College of Sports Science and Health, Capital University of Physical Education and Sports, Beijing 100191, China;
2.Beijing Institute of Hepatology Beijing You′an Hospital, Capital Medical University, Beijing 100069, China;
3.Qingdao University Medical College, Shandong Province, Qingdao 266071, China
Abstract：Objective To investigate the frequency distribution characteristics of α-actinin 3 (ACTN3) gene R577X polymorphism in northern HanZú and MongguZú populations. Methods From September to November 2019, a total of 85 northern HanZú people who participated in the health checkup at Beijing You′an Hospital and a total of 58 health checkup population from the 2019 preparatory class of MongguZú in Baotou Medical College were selected as the research objects. High-throughput fluorescence real-time quantitative polymerase chain reaction was used to analyze the R577X polymorphism of ACTN3 gene of different races and genders. Results The three genotypes were in accordance with Hardy-Weinberg equilibrium in different groups of people. The genotype frequency (RR) and allele frequency (R) of the northern HanZú population were higher than those of the MengguZú population, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the distribution of ACTN3 gene R577X genotypes between different genders of northern HanZú and MongguZú (P ＞ 0.05). The differences in different genotype frequencies, and different allele frequencies were no statically signifrcant between the northern HanZú and the MongguZú in different genders (P ＞ 0.05). Conclusion The differences in ACTN3 gene R577X genotype frequency and allele frequency between northern HanZú and MongguZú populations have nothing to do with gender. RR genotype frequency related to explosive power is higher in northern HanZú population, while XX genotype frequency reflecting endurance in MongguZú population is higher.
吴剑1 高玉雪2 杨鹏翔3 郭向华2. 北方汉族和蒙古族人群中运动能力差异相关基因ACTN3多态性研究[J]. 中国医药导报, 2020, 17(25): 38-41.
WU Jian1 GAO Yuxue2 YANG Pengxiang3 GUO Xianghua2. Study on ACTN3 gene polymorphism related to the difference of athletic ability in Northern HanZú and MongguZú population. 中国医药导报, 2020, 17(25): 38-41.
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2020, Vol. 17 
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