Value of ESAT-6 combined with MMP-14 in the evaluation of HIV patients with tuberculosis
LU Nihong1 XIA Jiawei2 LIU Honglu1 LIU Jun3▲
1.Department of Respiratory and Critical Care Medicine, Kunming Third People′s Hospital, Yunnan Province, Kunming 650041, China;
2.Department of Critical Care Medicine, Kunming Third People′s Hospital, Yunnan Province, Kunming 650041, China;
3.Department of STD and AIDS, Kunming Third People′s Hospital, Yunnan Province, Kunming 650041, China
Abstract：Objective To explore the value of early secretion of targeted antigen (ESAT-6) and matrix metalloproteinase 14 (MMP-14) in the evaluation of the severity of human immunodeficiency virus (HIV) patients with tuberculosis. Methods A retrospective analysis was made on 42 cases of HIV complicated with tuberculosis infection(group A), 50 cases of tuberculosis infection (group B) and 21 people of health examination (group C) in outpatient clinic from July 2018 to July 2019 in Kunming Third People′s Hospital. Fasting venous blood was taken to detect ESAT-6, MMP-14 and immune function. Results The expression of ESAT-6 in the three groups were compared, and the difference were statistically significant (P ＜ 0.05), while there was no expression in group C. Comparison of the levels of MMP-14, CD4+T, CD8+T and CD3+T cells in the three groups showed statistically significant differences (P ＜ 0.05). Among them, the MMP-14 of patients in group A and B were higher than those in group C, while group A was higher than that in group B, and the differences were statistically significant (P ＜ 0.05); the levels of CD4+T, CD8+T and CD3+T cells in group A and B were lower than those in group C, while group A was lower than that in group B, and the differences were statistically significant (P ＜ 0.05). ESAT-6 was negatively correlated with the expression of CD4+ T and CD8+ T (r = -0.34, -0.48, P ＜ 0.05). The expression of MMP-14 was negatively correlated with the expression of CD4+ T, CD8+ T, and CD3+ T (r = -0.32, -0.33, -0.54, P ＜ 0.05). MMP-14 was positively correlated with the severity of the disease (r = 0.78, P = 0.00). Conclusion The expression of ESAT-6 and MMP-14 are increased in severely ill patients with HIV and tuberculosis, and MMP-14 is significantly increased in severely ill patients. Both are closely related to disease progression, and the prognosis of these patients can be further evaluated.
陆霓虹1 夏加伟2 刘洪璐1 刘俊3▲. ESAT-6联合MMP-14检测在HIV并肺结核患者病情评估中价值[J]. 中国医药导报, 2020, 17(23): 115-118.
LU Nihong1 XIA Jiawei2 LIU Honglu1 LIU Jun3▲. Value of ESAT-6 combined with MMP-14 in the evaluation of HIV patients with tuberculosis. 中国医药导报, 2020, 17(23): 115-118.
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2020, Vol. 17 
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