Abstract：Objective To observe the effect of Propofol combined with Sevoflurane anesthesia on brain index and cognitive function in children under general anesthesia. Methods According to the difference of anesthesia methods during operation, a total of 96 children undergoing general anesthesia in Xinyi People′s Hospital, Jiangsu Province were divided into simple group (epidural Propofol anesthesia) and compound group (epidural Propofol + laryngeal mask Sevoflurane anesthesia) with 48 cases in each group. The brain index between the two groups 1 min before anesthesia and 30 min after anesthesia, cognitive function scores before and 3 days after surgery, and adverse reactions during and after surgery were compared. Results Compared with 1 min before anesthesia, the brain index of children in the simple group were significantly reduced 30 minutes after anesthesia, while the composite group were significantly lower than those in the simple group, and the differences were statistically significant (P ＜ 0.05). Compared with before surgery, the Montreal cognitive assessment scale scores of children in the simple group were significantly decreased on 3 days after surgery, while the composite group were significantly higher than those in the simple group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the adverse reaction rate between the two groups (P ＞ 0.05). Conclusion Simple epidural Propofol general anesthesia has a certain effect on the brain index and cognitive function in children after surgery, but Propofol combined with Sevoflurane has little effect on the brain index and cognitive function in children after general anesthesia.
吴书宝1 程伟2. 丙泊酚复合七氟醚对小儿全身麻醉术后脑指数及认知功能影响[J]. 中国医药导报, 2020, 17(19): 108-111.
WU Shubao1 CHENG Wei2. Effect of Propofol combined with Sevoflurane on brain index and cognitive function after general anesthesia in children. 中国医药导报, 2020, 17(19): 108-111.
2020, Vol. 17 
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