Study on correlation between damp heat constitution and inflammatory markers in obesity patients
ZHANG Xufeng1 JIN Xin2 LIU Zhenxiu3 WU Jiayun3 TAO Feng2 ZHU Yunhua4 ZHANG Xiaotian4
1.Department of Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
2.Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
3.Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
4.Department of Preventive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Abstract：Objective To explore the correlation between damp heat constitution and inflammatory markers in obese patients. Methods Eighty obesity outpatients from Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine and eighty normal weight physical examinees from January 2018 to June 2019 in Department of Preventive Medicine were selected and divided into four groups: obesity damp heat group (40 cases), obesity calmness group (40 cases), normal weight damp heat group (40 cases) and normal weight calmness group (40 cases). Body mass index, waist circumference, body fat rate, trunk fat rate, inflammatory markers (tumor necrosis factor α [TNF-α], interleukin-6 [IL-6], C-reactive protein [CRP] and leptin) and metabolic indexes were compared in each group. The correlation between inflammatory markers and the score of damp heat quality in obesity patients was analyzed. Results There was significant difference in the scores of damp heat quality among four groups (P < 0.05). There were significant differences in body mass index, waist circumference, body fat rate and trunk fat rate among four groups (P < 0.05). The body mass index, waist circumference, body fat rate and trunk fat rate of obesity damp heat group and obesity calmness group were all higher than those of normal weight damp heat group and normal weight calmness group (P < 0.05). The waist circumference, body fat rate and trunk fat rate of obesity damp heat group were higher than those of obesity calmness group (P < 0.05). The levels of TNF-α, IL-6, CRP and leptin among four groups were significantly different (P < 0.05). The levels of TNF-α in obesity damp heat group and obesity calmness group were higher than those in normal weight calmness group (P < 0.05). The level of TNF-α in obesity damp heat group was higher than that in obesity calmness group and normal weight damp heat group (P < 0.05). The levels of IL-6 and CRP in obesity damp heat group were higher than those in normal weight calmness group (P < 0.05). The levels of leptin in obesity damp heat group, obesity calmness group and normal weight damp heat group were higher than those in normal weight calmness group (P < 0.05). The levels of leptin in obesity damp heat group and obesity calmness group were higher than those in normal weight damp heat group (P < 0.05). The level of leptin in obesity damp heat group was higher than that in obesity calmness group (P < 0.05). The glycosylated hemoglobin (HbA1c) and triacylglycerol (TG) levels among four groups were significantly different (P < 0.05). HbA1c level of obesity damp heat group was higher than that of normal weight calmness group and normal weight damp heat group (P < 0.05). TG level of obesity damp heat group was higher than that of normal weight calmness group (P < 0.05). There was a positive correlation between TNF-α, IL-6, leptin and the score of damp heat quality in obesity patients (r = 0.37, 0.11, 0.62, P < 0.05). Conclusion There is correlation between damp heat constitution and inflammatory markers. The former may be a tool to evaluate the chronic inflammatory level of obesity patients.
2020, Vol. 17 
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