Research progress on the relationship between exosomes and tissue fibrosis
HU Zhaoyong1 LIU Yanli2 XIE Saifei3 ZHENG Ling3 TAN Jin3▲
1.Anatomy Experiment Center, Medicine School, Hu′nan University of Chinese Medicine, Hu′nan Province, Changsha 410208, China;
2.Department of Diagnostics, Medicine School, Hu′nan University of Chinese Medicine, Hu′nan Province, Changsha 410208, China;
3.Department of Stomatology, the First Hospital of Hu′nan University of Chinese Medicine, Hu′nan Province, Changsha 410007, China
Abstract：Tissue fibrosis is a pathological process in which the necrosis of parenchymal cells is reduced and the fibrous connective tissue is increased, which can lead to the destruction of tissue and organ structure and loss of function, even threaten the health and life of human. Exosomes are tiny vesicles that can be secreted by almost all cells, carrying intracellular mRNA, protein and other substances, mediating intercellular communication and participating in various biological processes. In recent years, there have been more and more studies on the relationship between exosomes and fibrosis. This article mainly reviews from the perspective of exosomes regulating fibrosis, as biological markers for diagnosing fibrosis and therapeutic targets.
胡兆勇1 刘艳丽2 谢赛飞3 郑玲3 谭劲3▲. 外泌体与组织纤维化关系的研究进展[J]. 中国医药导报, 2020, 17(15): 34-36,40.
HU Zhaoyong1 LIU Yanli2 XIE Saifei3 ZHENG Ling3 TAN Jin3▲. Research progress on the relationship between exosomes and tissue fibrosis. 中国医药导报, 2020, 17(15): 34-36,40.
[1] Yoshioka Y，Ochiya T. Investigation into the identities of circulating exosomes [J]. Rinsho Ketsueki，2016，57（10）：1874-1880.
[2] Akers JC，Gonda D，Kim R，et al. Biogenesis of extracellular vesicles（EV）：exosomes，microvesicles，retrovirus-like vesicles，and apoptotic bodies [J]. J Neurooncol，2013，113（1）：1-11.
[3] Lee Y，El Andaloussi S，Wood MJ. Exosomes and microvesicles：extracellular vesicles for genetic information transfer and gene therapy [J]. Hum Mol Genet，2012，21（R1）：R125-R134.
[4] Borges FT，Melo SA，Ozdemir BC，et al. TGF-beta1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis [J]. J Am Soc Nephrol，2013，24（3）：385-392.
[5] Quan J，Lu Z，Yu L，et al. Research progress of exosomes in epithelial-mesenchymal transition [J]. Nan Fang Yi Ke Da Xue Xue Bao，2019，39（3）：377-380.
[6] Min H，Sun X，Yang X，et al. Exosomes Derived from Irradiated Esophageal Carcinoma-Infiltrating T Cells Promote Metastasis by Inducing the Epithelial-Mesenchymal Transition in Esophageal Cancer Cells [J]. Pathol Oncol Res，2018，24（1）：11-18.
[7] Diepenbruck M，Christofori G. Epithelial-mesenchymal transition（EMT）and metastasis：yes，no，maybe? [J]. Curr Opin Cell Biol，2016，4（3）：7-13.
[8] Yao Y，Chen R，Wang G，et al. Exosomes derived from mesenchymal stem cells reverse EMT via TGF-beta1/Smad pathway and promote repair of damaged endometrium [J]. Stem Cell Res Ther，2019，10（1）：1-17.
[9] Chen L，Charrier A，Zhou Y，et al. Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells [J]. Hepatology，2014，59（3）：1118-1129.
[10] Qu Y，Zhang Q，Cai X，et al. Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation [J]. J Cell Mol Med，2017，21（10）：2491-2502.
[11] Li T，Yan Y，Wang B，et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis [J]. Stem Cells Dev，2013，22（6）：845-854.
[12] Zhu F，Chong Lee Shin OLS，Pei G，et al. Adipose-derived mesenchymal stem cells employed exosomes to attenuate AKI-CKD transition through tubular epithelial cell dependent Sox9 activation [J]. Oncotarget，2017，8（41）：70707-70726.
[13] Wang L，Liu J，Xu B，et al. Reduced exosome miR-425 and miR-744 in the plasma represents the progression of fibrosis and heart failure [J]. Kaohsiung J Med Sci，2018， 34（11）：626-633.
[14] Du X，Pan Z，Li Q，et al. SMAD4 feedback regulates the canonical TGF-beta signaling pathway to control granulosa cell apoptosis [J]. Cell Death Dis，2018，9（2）：151-152.
[15] 兰蓓蓓，王娟娟，邵联波，等.间充质干细胞来源的外泌体通过TGF-β1/Smad2/3信号通路抑制高糖诱导的成纤维细胞转分化[J].中国细胞生物学学报，2017，39（7）：916-925.
[16] Choi M，Ban T，Rhim T. Therapeutic use of stem cell transplantation for cell replacement or cytoprotective effect of microvesicle released from mesenchymal stem cell [J]. Mol Cells，2014，37（2）：133-139.
[17] Li L，Li C，Wang S，et al. Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype [J]. Cancer Res，2016，76（7）：1770-1780.
[18] Thum T，Gross C，Fiedler J，et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts [J]. Nature，2008，456（7224）：980-984.
[19] Lv LL，Cao YH，Ni HF，et al. MicroRNA-29c in urinary exosome/microvesicle as a biomarker of renal fibrosis [J]. Am J Physiol Renal Physiol，2013，305（8）：F1220-F1227.
[20] Sole C，Cortes-Hernandez J，Felip ML，et al. miR-29c in urinary exosomes as predictor of early renal fibrosis in lupus nephritis [J]. Nephrol Dial Transplant，2015，30（9）：1488-1496.
[21] Liu C，Su C. Design strategies and application progress of therapeutic exosomes [J]. Theranostics，2019，9（4）：1015-1028.
[22] El Andaloussi S，Lakhal S，Mager I，et al. Exosomes for targeted siRNA delivery across biological barriers [J]. Adv Drug Deliv Rev，2013，65（3）：391-397.
[23] O′Loughlin AJ，Woffindale CA，Wood MJ. Exosomes and the emerging field of exosome-based gene therapy [J]. Curr Gene Ther，2012，12（4）：262-274.
[24] Johnsen KB，Gudbergsson JM，Skov MN，et al. A comprehensive overview of exosomes as drug delivery vehicles-endogenous nanocarriers for targeted cancer therapy [J]. Biochim Biophys Acta，2014，1846（1）：75-87.
[25] Wang B，Yao K，Huuskes BM，et al. Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis [J]. Mol Ther，2016，24（7）：1290-1301.
2020, Vol. 17 
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