1.The First Clinical College, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430061, China;
2.Department of Rheumatism Immunology, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Province, Wuhan 430061, China;
3.Xiangnan Famous Medical Studio, Hubei Province, Wuhan 430061, China;
4.Department of Geriatrics, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Province, Wuhan 430061, China;
5.College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430061, China;
6.College of Basic Medical, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430061, China
Abstract：Objective To study the prevalence of thyroid disease in patients with systemic lupus erythematosus and associated risk factors of Hashimoto′s thyroiditis and subclinical hypothyroidism in systemic lupus erythematosus, so as to provide evidence for clinical prevention and treatment. Methods Sixty-six patients with systemic lupus erythematosus hospitalized in Hubei Hospital of Traditional Chinese Medicine from May 2017 to May 2019 were selected as the study subjects. Among them, a total of 15 cases with Hashimoto′s thyroiditis were observation group A, 26 cases without Hashimoto′s thyroiditis were control group A; a total of 9 cases with subclinical hypothyroidism were observation group B, a total of 52 cases without subclinical hypothyroidism were control group B. The incidence of thyroid disease in systemic lupus erythematosus was observed, and the general condition (gender, age, course of disease), blood analysis, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), immune function, thyroid function, blood lipid (triacylglycerol [TG], high density lipoprotein cholesterol [HDL-C]), uric acid (UA), ENA antibody spectrum, anti-nuclear antibodies (ANA), albumin level (ALB) and clinical manifestations were statistically processed. Results Except for age, there was no statistically significant difference between group A and control group A patients (P ＞ 0.05). Age was an independent risk factor for systemic lupus erythematosus complicated with Hashimoto′s thyroiditis (OR [95%CI] = 1.064[1.004, 1.128], P ＜ 0.05). Except for immunoglobulin M (IgM) and anti-Ds-DNA antibody positive (Ds-DNA), there was no statistically significant difference between other indicators of group B and control group B (P ＞ 0.05). Anti-Ds-DNA antibody was an independent risk factor for systemic lupus erythematosus complicated with subclinical hypothyroidism (OR [95%CI] = 10.573[1.673, 66.810], P ＜ 0.05). Conclusion The incidence of systemic lupus erythematosus complicated with thyroid disease is high. Hashimoto′s thyroiditis and subclinical hypothyroidism are relatively common thyroid diseases. Age is an independent risk factor for systemic lupus erythematosus complicated with Hashimoto′s thyroiditis. Anti-Ds-DNA antibody is an independent risk factor for systemic lupus erythematosus complicated with subclinical hypothyroidism.
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2020, Vol. 17 
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