Research on the main factors affecting the chemical composition of Eucommia ulmoides Oliv.
LIU Kun1 PAN YingYi1 WANG Jianying2 CHENG Xiaoyun3 YUAN Ying1
1.School of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
2.Collaborative Innovation Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
3.Department of Rheumatology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Abstract:This article reviews the chemical composition of Eucommia ulmoides Oliv. from different medicinal parts, processing methods, producing area, collection time and serum drug metabolism. It is found that the influence of different medicinal parts of Eucommia ulmoides Oliv. on the chemical composition is mainly reflected in the great difference in the content of effective components and the representative components of each part. The influence of collection time in producing area is mainly manifested in the obvious difference of chemical composition content. The processing methods of Eucommia ulmoides Oliv. mainly changes the structure of its chemical composition and the ratio of its species. The chemical components of Eucommia ulmoides Oliv. are still prototype after drug metabolism, but the pharmacokinetic characteristics of each component are quite different. This article also combines five main influencing factors to elaborate the relevant drug effects. It may provide a reference to explain the material basis of Eucommia ulmoides Oliv. exerting different drug effects to a certain extent, and may also provide a reference for the clinical application and resource development of Eucommia ulmoides Oliv..
刘锟1 潘颖宜1 王健英2 陈晓云3 袁颖1. 杜仲化学成分的主要影响因素概况[J]. 中国医药导报, 2020, 17(12): 41-44.
LIU Kun1 PAN YingYi1 WANG Jianying2 CHENG Xiaoyun3 YUAN Ying1. Research on the main factors affecting the chemical composition of Eucommia ulmoides Oliv.. 中国医药导报, 2020, 17(12): 41-44.
[1] 陈建明.关于杜仲的概述[J].遵义科技,2004,11(3):142-146.
[2] 刘聪,郭非非,肖军平,等.杜仲不同部位化学成分及药理作用研究进展[J].中国中药杂志,2019,12(25):1-18
[3] 范彦博,周妍,刘大鹏,等.杜仲主要化学成分分类总结[J].中国药师,2014,17(10):1756-1760.
[4] 左月明,张忠立,王彦彦,等.杜仲叶环烯醚萜类化学成分研究[J].中药材,2014,37(2):252-254.
[5] 王娟娟,秦雪梅,高晓霞,等.杜仲化学成分、药理活性和质量控制现状研究进展[J].中草药,2017,48(15):3228-3237.
[6] 冯晗,周宏灏,欧阳冬生.杜仲的化学成分及药理作用研究进展[J].中国临床药理学与治疗学,2015,20(6):713-720.
[7] He X,Wang J,Li M,et al. Eucommia ulmoides Oliv.:Ethnopharmacology,phytochemistry and pharmacology of an important traditional Chinese medicine [J]. J Ethnopharmacol,2014,151(1):78-92.
[8] 梁依芳.杜仲的现代研究进展[J].中国中医药现代远程教育,2016,14(23):151-152.
[9] 王双燕,丁林芬,吴兴德,等.杜仲化学成分研究[J].中药材,2014,37(5):807-811.
[10] 张忠立,左月明,王彦彦,等.杜仲叶环烯醚萜类化学成分研究[J].中药材,2014,37(2):252-254.
[11] 马长乐,李靖,刘小烛.杜仲抗真菌蛋白的时空表达特性[J].贵州农业科学,2012,40(8):169-170.
[12] 陶益,盛辰,李伟东,等.杜仲不同炮制品化学成分研究[J].中国中药杂志,2014,39(22):4352-4355.
[13] 侯晓杰,张建锋,李玮.杜仲不同部位的加工方法对其质量影响的研究进展[J].安徽农业科学,2018,46(1):37-38,41.
[14] 钟淑娟,杨欣,李静,等.杜仲不同部位总黄酮含量及抗氧化活性研究[J].中国药房,2017,28(13):1787-1790.
[15] 阿来·赛坎.杜仲叶的品质评价研究[D].乌鲁木齐:新疆医科大学,2017.
[16] 齐武强,王明昭.杜仲叶和杜仲皮中化学成分的比较[J].临床医学研究与实践,2017,2(11):121-122,124.
[17] 张帅男,李煦照.杜仲化学成分及药理作用研究进展[J].中国民族民间医药,2017,26(10):56-61.
[18] 杜庆鑫,魏艳秀,刘攀峰,等.分光光度法测定杜仲雄花和叶中的总黄酮[J].中南林业科技大学学报,2017,37(5):96-100.
[19] 严颖,赵慧,邹立思,等.杜仲雄花化学成分的液相色谱-电喷雾三重四极杆飞行时间质谱分析[J].食品科学,2018,39(6):196-221.
[20] 栾庆祥.杜仲化学成分和药理作用研究进展[J].安徽农业科学,2016,44(9):153-156.
[21] Zhang ZS,Liu YL,Che LM. Optimization of Supercritical Carbon Dioxide Extraction of Eucommia ulmoides Seed Oil and Quality Evaluation of the Oil [J]. J Oleo Sci,2018, 67(3):255-263.
[22] 徐婧.杜仲籽粕中桃叶珊瑚苷的分离纯化及化学成分的研究[D].开封:河南大学,2014.
[23] 梅蛟,杨帆.杜仲治疗高血压研究进展[J].世界最新医学信息文摘,2018,18(81):35-36.
[24] 白璧辉,谢兴文,李鼎鹏,等.杜仲及其有效成分防治骨质疏松症研究进展[J].辽宁中医药大学学报,2019,21(1):126-129.
[25] Lee GH,Lee MR,Lee HY,et al. Eucommia ulmoides cortex,geniposide and aucubin regulate lipotoxicity through the inhibition of lysosomal BAX [J]. PLoS One,2014,9(2):88017.
[26] 李雨桐. 桃叶珊瑚苷通过Nrf2/Keapl信号通路促进成骨细胞分化抑制骨质疏松作用的研究[D].长春:吉林大学,2019.
[27] 邓翀,韩磊,张亚强,等.杜仲盐制前后化学成分的变化[J].中成药,2015,37(11):2464-2468.
[28] 侯惺,李娟,贾方真,等.盐炙对杜仲丸HPLC指纹图谱化学成分群的影响[J].中医药导报,2019,25(19):49-52.
[29] 郑艳萍,徐虹,秦昆明,等.不同干燥方式对杜仲叶4种活性成分含量的影响[J].中国药房,2017,28(28):3973-3976.
[30] 韩磊,郭亚敏.杜仲盐炙入肾文献研究[J].科学技术创新,2019(1):24-25.
[31] 黄伟.杜仲不同产地遗传差异及化学组分分析[D].北京:中国林业科学研究院,2014.
[32] 唐芳瑞,刘荣华,邵峰,等.不同产地杜仲叶高效液相色谱指纹图谱分析[J].时珍国医国药,2016,27(6):1496-1498.
[33] 郑英,周兰,许亚玲,等.黔产杜仲叶不同采收期化学成分变化规律研究[J].世界最新医学信息文摘,2018,18(34):27-29.
[34] 杜庆鑫,魏艳秀,李钦,等.杜仲雄花生长发育动态及活性成分量变化[J].中草药,2017,48(13):2746-2751.
[35] He MZ,Jia J,Li J,et al. Application of characteristic ion filtering with ultra-high performance liquid chromatography quadrupole time of flight tandem mass spectrometry for rapid detection and identification of chemical profiling in Eucommia ulmoides Oliv. [J]. J Chromatogr A,2018, 1554:81-91.
[36] Jin JS,Zhao YF,Nakamura N,et al. Isolation and characterization of a human intestinal bacterium,Eubacterium sp. ARC-2,capable of demethylating arctigenin,in the essential metabolic process to enterolactone [J]. Biol Pharm Bull,2007,30(5):904-911.
[37] An J,Hu F,Wang C,et al. Pharmacokinetics and tissue distribution of five active ingredients of Eucommiae cortex in normal and ovariectomized mice by UHPLC-MS/MS [J]. Xenobiotica,2016,46(9):793-804.
[38] Li YJ,Gong ZP,Cao XU,et al. A UPLC-MS Method for Simultaneous Determination of Geniposidic Acid,Two Lignans and Phenolics in Rat Plasma and its Application to Pharmacokinetic Studies of Eucommia ulmoides Extract in Rats [J]. Eur J Drug Metab Pharmacokinet,2016, 41(5):595-603.
[39] 刘星,龚小见,陈华国,等.基于入血成分的杜仲药材的含量测定[J].中国中药杂志,2015,40(9):1771-1775.
[40] 王永林,向文英,陆苑,等.杜仲的血清药物化学研究[J].中草药,2016,47(7):1101-1105.
[41] Lafay S,Gil-Izquierdo A,Manach C,et al. Chlorogenic acid is absorbed in its intact form in the stomach of rats [J]. JNutr,2006,136(5):1192-1197.