Expression level and the diagnostic value of glial cell line-derived neurotrophic factor and Nod-like receptor protein 3 inflammatory in patients with depression
TIAN Haihua1 LIU Jimeng2 XU Guoan2 LI Guangxue2 WAN Xiaohan2,3 ZHANG Jiao2,3 GAO Shugui2
1.Department of Clinic Laboratory, Ningbo Kangning Hospital, Zhejiang Province, Ningbo 315201, China；
2.Department of Affective Disorder Ward, Ningbo Kangning Hospital, Zhejiang Province, Ningbo 315201, China；
3.Ningbo university School of Medicire, Zhejiang Province, Ningbo 315211, China
Abstract：Objective To investigate the changes of glial cell-derived neurotrophic factor (GDNF) and nod-like receptor protein 3 (NLRP3) inflammasome in major depressive disorder patients and analyze the diagnostic value. Methods A total of 100 patients with major depressive disorder admitted to the Department of Affective Disorder, Ningbo Kangning Hospital (“our hospital” for short) from January 2018 to June 2019 were selected as the depression group. A total of 60 healthy people underwent routine physical examination in our hospital during the same period were selected as the control group. The expression of serum GDNF and NLRP3 inflammasome were compared between the two groups of patients and patients with depression of different severity. The correlation between the severity of depression and the diagnostic efficacy of GDNF and NLRP3 inflammasome single test and combined test in diagnosing depression were calculated. Results The level of GDNF in the depression group was significantly lower than that of the control group, and the serum NLRP3 level of the inflamatome was significantly higher than that of the control group, with statistically significant differences (all P ＜ 0.05). The levels of GDNF and NLRP3 in patients with depression of different severity were statistically significant differences (P ＜ 0.05). Compared with the mild depression group, the GDNF level in the moderate depression group and the severe depression group were decreased and the NLRP3 inflammasome was increased, the differences were statistically significant (all P ＜ 0.05). Compared with the moderate depression group, the GDNF level in the severe depression group were decreased and the NLRP3 inflammasome was increased, the differences were statistically significant (all P ＜ 0.05). The expression level of GDNF was negatively correlated with the severity of depression (r = -0.603, P ＜ 0.05), while the expression level of serum NLRP3 inflamosome was positively correlated with the severity of depression (r = 0.762, P ＜ 0.05). The sensitivity and specificity of combined detection of GDNF and NLRP3 inflammasome in diagnosing depression were significantly higher than that of single detection of GDNF and NLRP3 inflammasome and the combined detection has good specificity. Conclusion The abnormal expression of GDNF and serum NLRP3 inflammarosome is closely related to the occurrence and development of depression, and the combined detection of GDNF and NLRP3 inflammarosome is helpful for the diagnosis and condition evaluation of depression.
田海华1 刘纪猛2 徐国安2 李广学2 万小晗2,3 张娇2,3 高树贵2. 抑郁症患者胶质细胞源性神经营养因子、Nod样受体蛋白3炎症小体表达水平及其诊断价值[J]. 中国医药导报, 2020, 17(8): 148-151.
TIAN Haihua1 LIU Jimeng2 XU Guoan2 LI Guangxue2 WAN Xiaohan2,3 ZHANG Jiao2,3 GAO Shugui2. Expression level and the diagnostic value of glial cell line-derived neurotrophic factor and Nod-like receptor protein 3 inflammatory in patients with depression. 中国医药导报, 2020, 17(8): 148-151.
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2020, Vol. 17 
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