Effects of acteoside on behavior and hormone changes of APP/PS1 double transgenic mice
CHEN Jiayuan1 GAO Li2 LUO Jianan2 LI Jianmei2 YAN Ming2▲
1.College of Pharmacy, Shihezi University, Xinjiang Uygur Autonomous Region, Shihezi 832003, China;
2.Key Laboratory of Medical Prescription, Uighur Medical Research Institute of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urmuqi 830011, China
Abstract：Objective To investigate the effects of acteoside on behavior and hormone changes of APP/PS1 double transgenic mice. Methods Ten mice of C57 BL/6J were selected as control (group A). 50 healthy APP/PS1 double transgenic mice were randomly divided into group B (model), group C (Donepezil), group D (low dose of acteoside), group E (medium dose of acteoside), group F (high dose of acteoside), 10 mice in each group. After 120 days of continuous administration, O maze test was carried out, and Aβ1-40 content in hippocampus of mice and the hormone content in serum and pituitary gland were determined. Results Compared with group A, the distance and time of arm opening in group B were significantly shortened (P < 0.05); compared with group B, the distance and time of arm opening in group D were significantly lengthened (P < 0.01), and the distance of arm opening in group E was lengthened (P < 0.05). Compared with group A, the content of Aβ1-40 in group B increased significantly (P < 0.01); compared with group B, the content of Aβ1-40 in group E decreased significantly (P < 0.01). Compared with group A, the content of adrenocorticotropic hormone in group B was significantly increased (P < 0.05); compared with group B, the content of adrenocorticotropic hormone in group C and group F was significantly decreased, and the content of cortisol in group F was significantly decreased (P < 0.05). Compared with group B, follicle-stimulating hormone content in pituitary gland of group D decreased significantly (P < 0.05). Compared with group A, thyroid-stimulating hormone content of group B was significantly decreased (P < 0.05); compared with group B, thyroid-stimulating hormone content of group C, group E and group F was significantly increased (P < 0.05 or P < 0.01). Compared with group A, growth hormone content in pituitary of group B decreased significantly (P < 0.05); compared with group B, growth hormone content of group C, group E and group F increased significantly (P < 0.05 or P < 0.01). Conclusion Acteoside can improve the anxiety emotion of APP/PS1 double transgenic mice, protect the cerebral neural circuit and improve the memory ability by regulating the content of Aβ1-40 and the hormone secretion.
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2020, Vol. 17 
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