血清淀粉样蛋白A检测在肺炎支原体肺炎中的诊断价值

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摘要目的探讨血清淀粉样蛋白A（SAA）在肺炎支原体肺炎（MPP）中的诊断价值。方法收集2019年3～6月柳州市妇幼保健院（以下简称“我院”）儿科住院部的MPP患儿130例作为MPP组，另选同期在我院儿童保健科体检的健康儿童100例作为对照组。比较两组全血SAA、C-反应蛋白（CRP）、白细胞（WBC）及血清肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）、α-羟基丁酸脱氢酶（HBDH）水平，分析MPP组SAA与其他指标的相关性，利用ROC曲线分析SAA、CRP、WBC对MPP的诊断效能。结果 MPP组SAA、CRP、WBC水平高于对照组，差异均有统计学意义（均P ＜ 0.05），SAA与CRP、WBC均呈正相关（r = 0.760、0.369，P ＜ 0.05），与CK、CK-MB、LDH、HBDH无相关性（P ＞ 0.05）。以SAA、CRP、WBC为变量绘制MPP的ROC曲线，ROC曲线下面积分别为0.942、0.689、0.618，预测MPP的灵敏性分别为81.2%、75.4%、56.2%，特异度分别为90.3%、93.0%、63.0%。结论 SAA水平检测可作为MPP的监测指标，对MPP的辅助诊断具有重要意义。

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	冼肖英丁燕玲▲

关键词 ：肺炎支原体肺炎, 血清淀粉样蛋白A, C-反应蛋白, 白细胞

Abstract：Objective To investigate the diagnostic value of serum amyloid A protein (SAA) in Mycoplasma pneumoniae pneumonia (MPP). Methods A total of 130 children with MPP who came to the pediatric inpatient department of Liuzhou Maternal and Child Healthcare Hospital (hereinafter referred to as “our hospital”) from march to June 2019 were collected as the MPP group, and 100 healthy children who underwent physical examination in the child healthcare department of our hospital during the same period were selected as the control group. The levels of SAA, C-reactive protein (CRP), white blood cell (WBC) in whole blood and serum creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (HBDH) were compared between the two groups. The correlation between SAA and other indicators in MPP group was analyzed, and the diagnostic efficacy of SAA, CRP and WBC on MPP was analyzed by ROC curve. Results The levels of SAA, CRP and WBC in MPP group were higher than those in control group, with statistically significant differences (all P ＜ 0.05). SAA was positively correlated with CRP and WBC (r = 0.760, 0.369, P ＜ 0.05). There was no correlation between SAA, CK, CK-MB, LDH and HBDH (P ＞ 0.05). The ROC curve of MPP was drawn with SAA, CRP and WBC as variables. The area under the ROC curve was 0.942, 0.689 and 0.618, respectively. The sensitivity of MPP was 81.2%, 75.4% and 56.2%, and the specificity was 90.3%, 93.0% and 63.0%, respectively. Conclusion SAA level detection can be used as the monitoring index of MPP and is of great significance to the auxiliary diagnosis of MPP.

Key words： Mycoplasma pneumoniae pneumonia Serum amyloid A protein C-reactive protein White blood cells

基金资助:广西壮族自治区卫生健康委员会自筹经费科研课题（Z20190038、Z20190359、Z20190375）。

通讯作者: ▲通讯作者

引用本文:

冼肖英丁燕玲▲. 血清淀粉样蛋白A检测在肺炎支原体肺炎中的诊断价值[J]. 中国医药导报, 2020, 17(7): 168-171.
XIAN Xiaoying DING Yanling▲. Diagnostic value of serum amyloid A in Mycoplasma pneumoniae pneumonia. 中国医药导报, 2020, 17(7): 168-171.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I7/168

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