Abstract：Objective To investigate the effect of different increasing infusion rates of enteral nutrition on patients with severe acute pancreatitis. Methods Sixty patients with severe acute pancreatitis admitted to Yan′an People′s Hospital from February 2016 to February 2019 were divided into the low-speed group (30 cases) and the high-speed group (30 cases) according to the random paper method. The initial infusion rate was set to 30 mL/h. The enteral nutrition in the low-speed group began to increase at a rate of 10 mL/h, and gradually increased to 80 mL/h after 20 h. The enteral nutrition in the high-speed group increased at a rate of 20 mL/h, and gradually increased to 80 mL/h after 12 h. The intra-abdominal pressures were compared between the two groups before, at 8, 16 h and 20 h after the intervention. The micronutrient nutrition assessment scores form (MNA-SF), serum albumin (ALB), serum prealbumin (PB) levels at 10 days after the intervention, and the incidence of enteral nutritional intolerance of two groups were measured. Results There was no significant difference in the intra-abdominal pressure before intervention between the two groups (P ＞ 0.05). The intra-abdominal pressure at 8, 16 h and 20 h after the intervention were lower in the two groups than before the intervention, and the differences were statistically significant (P ＜ 0.05). The abdominal pressure after intervention in the high-speed group was significantly higher than that in the low-speed group, and the difference was statistically significant (P ＜ 0.05). In addition, there was an interaction between groups and time (P ＜ 0.05). There was no significant difference in MNA-SF, ALB, and PA between the two groups of patients before and 10 days after the intervention (P ＞ 0.05). The ALB and PA at 10 days after the intervention were higher in the two groups than those before the intervention, and the differences were statistically significant (P ＜ 0.05). The incidence of enteral nutrition intolerance in patients with low-speed group was lower than that in high-speed group, and the difference was statistically significant (P ＜ 0.05). Conclusion Severe acute pancreatitis with low infusion rate enteral nutrition has less intra-abdominal pressure and better feeding tolerance, which is worthy of clinical application.
刘娟1 冯秀1 白晶莹2▲. 肠内营养不同递增输注速度对重症急性胰腺炎患者的影响[J]. 中国医药导报, 2020, 17(7): 102-105.
LIU Juan1 FENG Xiu1 BAI Jingying2▲. Effect of different increasing infusion rates of enteral nutrition on patients with severe acute pancreatitis. 中国医药导报, 2020, 17(7): 102-105.
2020, Vol. 17 
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