Meta-analysis of the association between adenosine deaminase and rheumatoid arthritis
CAI Xintian ZHU Qing WU Ting LI Nanfang
Center of Hypertension Diagnosis and Treatment Research, Xinjiang Uygur Municipal People′s Hospital National Health Committee Key Laboratory of Hypertension Diagnosis and Treatment Research, Xinjiang Uygur Autonomous Region, Urumqi 830000, China
Abstract：Objective To systematically evaluate the association between adenosine deaminase (ADA) level and rheumatoid arthritis (RA). Methods Published literatures on the correlation between ADA level and RA in PubMed, Embase, Cochrane Library, Web of Science, China national knowledge infrastructure and wanfang database were searched. The retrieval time was from the database construction to June 1, 2019. Chinese keywords were adenosine deaminase, adenosine amino hydrolase, rheumatoid arthritis, wind–lik. English keywords were ADA, Adenosine Deaminase, Adenosine Aminohydrolase, RA, Rheunatoid Arthritis. Two researchers shall independently conduct literature screening, quality evaluation and data extraction in accordance. In case of any dispute, both parties shall negotiate or a third party shall assist in adjudication and settlement. GetData Graph Digitizer 2.22 software was used to digitally convert and extract the data in the selected literature and Stata 12.0 software was used to merge the data, sensitivity analysis and publication bias evaluation were carried out. Results A total of 16 articles were enrolled, including 784 cases in the case group and 711 cases in the control group. Meta-analysis showed that the levels of ADA in the case group were significantly higher than those in the control group (SMD = 1.37, 95%CI:1.00-1.74, P < 0.05). After the exclusion of 6 literatures with significant influence on the results of meta-analysis, ADA levels in the case group were significantly higher than those in the control group, with statistically significant differences (SMD = 1.14, 95%CI: 0.90-1.38, P < 0.05). The results of Begg test and Egger test showed that there was no significant publication bias between the studies (P = 0.631, 0.629). Conclusion The levels of ADA in synovial fluid and serum of patients with RA are significantly higher these those of normal people. The levels of ADA in serum and synovial fluid are expected to become an important factor for the diagnosis and evaluation of the disease activity of RA.
蔡昕添 朱晴 吴婷 李南方. 腺苷脱氨酶水平与类风湿关节炎关系的荟萃分析[J]. 中国医药导报, 2020, 17(7): 81-85.
CAI Xintian ZHU Qing WU Ting LI Nanfang. Meta-analysis of the association between adenosine deaminase and rheumatoid arthritis. 中国医药导报, 2020, 17(7): 81-85.
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2020, Vol. 17 
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