Research progress on clinical application and mechanism of Chinese medicine in the treatment of pancreatic cancer
WANG Jiangwei1 SU Xiaolin1 ZHAO Wan1 WANG Qiuhong1,2
1.Key Laboratory of Basic and Applied Research of Beiyao, Ministry of Education Heilongjiang Provincial Key Laboratory of Research on the Material Basis of the Efficacy of Traditional Chinese Medicine and Natural Medicine, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.College of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong Province, Guangzhou 510006, China
Abstract:Pancreatic cancer is a kind of digestive system malignant tumor with concealed early manifestations, short survival period, high mortality and no radical treatment. When traditional Chinese medicine as a strong and effective adjuvant treatment combined with various conventional treatment of pancreatic cancer, it can achieve good synergistic effect. At the same time, it can reduce adverse reactions, tumor volume, pain and improve quality of life. This paper summarizes the clinical application of traditional Chinese medicine in the treatment of pancreatic cancer and its anti-tumor mechanism. It is expected to provide reference and help for the treatment of pancreatic cancer with traditional Chinese medicine and the research and development of new drugs in the future.
王江威1 苏晓琳1 赵婉1 王秋红1,2. 中药治疗胰腺癌的临床应用及作用机制研究进展[J]. 中国医药导报, 2020, 17(7): 31-34.
WANG Jiangwei1 SU Xiaolin1 ZHAO Wan1 WANG Qiuhong1,2. Research progress on clinical application and mechanism of Chinese medicine in the treatment of pancreatic cancer. 中国医药导报, 2020, 17(7): 31-34.
[1] Siegel RL,Miller KD,Jemal A. Cancer statistics,2016 [J]. CA Cancer J Clin,2016,66(1):7-30.
[2] Yadav D,Lowenfels AB. The epidemiology of pancreatitis and pancreatic Cancer [J]. Gastroenterology,2013,144(6):1252-1261.
[3] 赵亚东,杨金坤,赵爱光,等.中药复方辨证治疗对胰腺癌R0切除术后无病生存期的影响[J].上海中医药大学学报,2014,28(5):35-37.
[4] 林文,王凯,马利红.中药超声电导在胰腺癌术后肠道功能恢复中的疗效观察[J].护士进修杂志,2015,4(30):724-725.
[5] 黄樱慧,卢中莲,招彩彬.山甲白花汤治疗胰腺癌的效果观察[J].当代医药论丛,2018,16(19):184-185.
[6] 刘奇志.小柴胡汤加味方联合替吉奥治疗Ⅲ、Ⅳ期胰腺癌的临床观察[D].长沙:湖南中医药大学,2017.
[7] 黄琪,刘华.膈下逐瘀汤加味方联合伽马刀治疗胰腺癌气滞血瘀证临床观察[J].湖南中医杂志,2017,33(3):8-10.
[8] 陆运鑫,卢旭全,吴发胜,等.益气健脾化瘀方联合射波刀治疗胰腺癌疗效观察[J].现代中西医结合杂志,2019, 28(6):593-596.
[9] 周素芹,周爱军,章一凡,等.调脾抑胰方加减联合高强度聚焦超声治疗局部晚期胰腺癌临床研究[J].四川中医,2019,37(2):107-109.
[10] 王春雨,张虹,王恩燕.自拟疏肝健脾方联合HIFU治疗晚期胰腺癌的临床观察[J].现代消化及介入诊疗,2018,23(3):329-331.
[11] 徐步远,杨伟青,施书强.NF-κB在大黄素联合吉西他滨治疗裸鼠胰腺癌肝转移中的作用[J].中华中医药学刊,2014,32(10):2500-2503.
[12] Duan JJ,Yue W,E JY,et al. In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation,apoptosis,and STAT3 and NF-κB signaling in pancreatic cancer cells [J]. Sci Rep,2016,6(1):31672.
[13] 何春游,张法灿,郭先文,等.苦参碱对胰腺癌CFPAC-1细胞增殖、凋亡及Hedgehog信号通路的影响[J].世界华人消化杂志,2016,24(3):338-346.
[14] Li W,Ma J,Ma Q,et al. Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI3K/Akt/NF-κB pathway [J]. Curr Med Chem,2013,20(33):4185-4194.
[15] Tian X,Dai SD,Sun J,et al. Bufalin induces mitochondria-dependent apoptosis in pancreatic and oral cancer cells by downregulating hTERT expression via activationof the JNK/p38 pathway [J]. Evid Based Complement Alternat Med,2015,2015:546210.
[16] Jing L,Xiang ST,Zhang QH,et al. Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C [J]. J Exp Clin Canc Res,2015,34(1):1-11.
[17] Aggarwal BB,Banerjee S,Bharadwaj U,et al. Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines [J]. Biochem Pharmacol,2007,73(7):1024-1032.
[18] Kato A,Naiki-Ito A,Nakazawa T,et al. Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2 [J]. Oncotarget,2015,6(40):42963-42975.
[19] 陈敏远,徐锦波,王兆洪,等.大黄素抑制胰腺癌裸鼠原位移植瘤新生血管形成的机制研究[J].浙江医学,2019, 41(8):735-738.
[20] 徐锦波,陈敏远,徐宏涛.大黄素通过调节TGF-β1、Smad4抑制人胰腺癌的血管生成[J].医学研究杂志,2017,46(10):162-165.
[21] 李楠.大黄素通过升高miRNA-1271抑制胰腺癌EMT作用机制的研究[D].天津:天津医科大学,2017.
[22] 杨庆龙.和厚朴酚对胰腺癌细胞株SW1990迁移与侵袭的抑制作用及机制的实验研究[D].苏州:苏州大学,2017.
[23] 王文龙,孔庆志,卢宏达,等.大黄素通过下调多药耐药基因-1的表达改善胰腺癌细胞对吉西他滨的耐药研究[J].中国临床药理学杂志,2018,34(20):2427-2430.
[24] 彭梦媛,邱峰,黄丹,等.姜黄素对胰腺癌SW1990细胞耐吉西他滨的逆转作用及机制研究[J].中国药房,2019, 30(9):1192-1197.
[25] 盛健,吴峰,夏甘霖,等.雷公藤甲素对胰腺癌干细胞的影响[J].医学导报,2014,33(3):315-317.
[26] Shankar S,Nall D,Tang S,et al. Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D trans-genic mice by inhibiting pluripotency maintaining factors and epithelialmesenchymal transition [J]. PLoS One,2011,6(1):e16530.