2型糖尿病患者颈围与良性前列腺增生的相关性研究

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摘要目的探讨2型糖尿病（T2DM）患者颈围（NC）与良性前列腺增生（BPH）的相关性。方法选取2015年9月~2017年6月冀中能源峰峰集团有限公司总医院内分泌科住院的男性T2DM患者216例，根据是否合并BPH，将其分为N-BPH组（n = 118）及BPH组（n = 98例）。根据NC测量水平将其分为四个亚组，分别为：Q1亚组（33.4 cm≤NC≤35.7 cm），53例；Q2亚组（35.7 cm＜NC≤39.1 cm），56例；Q3亚组（39.1 cm＜NC≤39.9 cm），51例；Q4亚组（39.9 cm＜NC≤43.9 cm），56例。收集所有受试者的一般资料及临床资料，测量NC水平，所有受试者均行前列腺B超检查，并对所有受试者进行国际前列腺症状评分（IPSS），相关性分析采用logistic回归分析。结果 BPH组NC、体重指数（BMI）、腰围、腰臀比、收缩压（SBP）、舒张压（DBP）及糖化血红蛋白、空腹血糖（FPG）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇、三酰甘油水平明显高于N-BPH组，差异均有统计学意义（均P < 0.05）。Q2、Q3、Q4亚组前列腺体积（PV）高于Q1亚组，Q3、Q4亚组膀胱残余尿量（PVR）、IPSS评分高于Q1亚组，Q3、Q4亚组PV高于Q2亚组，Q4亚组IPSS评分高于Q2、Q3亚组，差异均有统计学意义（均P < 0.05）。logistic回归分析显示，NC、BMI、SBP、FPG是BPH发生的危险因素。结论 T2DM合并BPH患者NC明显增加，NC有可能成为T2DM合并BPH影响因子，具有临床意义。

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	商书霞1 卫峻枫2▲ 赵军魁3 段丽君1 牛耘1 孙秋杰4 周浩5

关键词 ：颈围, 良性前列腺增生, 2型糖尿病, 胰岛素抵抗

Abstract：Objective To investigate the correlation between neck circumference (NC) and benign prostatic hyperplasia (BPH) in patients with type 2 diabetes mellitus (T2DM). Methods From September 2015 to June 2017, 216 cases with T2DM in Jizhong Energy Fengfeng Group Hospital were recruited. According to whether BPH was combined or not, they were divided into N-BPH group (n = 118) and BPH group (n = 98). According to the NC measurement levels, they were divided into Q1 subgroup: 33.4 cm≤NC≤35.7 cm (n=53), Q2 subgroup: 35.7 cm＜NC≤39.1 cm (n = 56), Q3 subgroup: 39.1 cm＜NC≤39.9 cm (n = 51), Q4 subgroup: 39.9 cm＜NC≤43.9 cm (n = 56). The general and clinical data of all subjects were collected, and the NC levels were measured. All subjects underwent B-ultrasound examination of prostate, and the international prostate symptom score (IPSS) was performed for all subjects. Logistic regression analysis was used for correlation analysis. Results NC, body mass index (BMI), waist circumference, waist-hip ratio, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the levels of glycosylated hemoglobin, fasting plasma glucose (FPG), high density lipoprotein cholesterd (HDL-C)， total cholesterol and triglyceride in BPH group were significantly higher than those in N-BPH group, with statistically significant differences (all P < 0.05). The prostate volume (PV) of Q2, Q3 and Q4 subgroups was higher than that of Q1 subgroup, the postvoid residual (PVR) and IPSS scores of Q3 and Q4 subgroups were higher than those of Q1 subgroup, the PV of Q3 and Q4 subgroups was higher than that of Q2 subgroup, and the IPSS scores of Q4 subgroup were higher than those of Q2 and Q3 subgroups, with statistically significant differences (all P < 0.05). Logistic regression analysis showed that NC, BMI, SBP and FPG were risk factors for BPH. Conclusion NC is significantly increased in T2DM patients with BPH. NC may become an influencing factor for T2DM patients with BPH, which has clinical significance.

Key words： Neck circumference Benign prostatic hyperplasia Type 2 diabetes mellitus Insulin resistance

基金资助:河北省医学科学研究课题（20191176）。

通讯作者: ▲通讯作者

作者简介: 商书霞（1973.4-），女，硕士，主任医师，硕士生导师；研究方向：内分泌及代谢。

引用本文:

商书霞1 卫峻枫2▲ 赵军魁3 段丽君1 牛耘1 孙秋杰4 周浩5. 2型糖尿病患者颈围与良性前列腺增生的相关性研究[J]. 中国医药导报, 2020, 17(6): 77-80.
SHANG Shuxia1 WEI Junfeng2▲ ZHAO Junkui3 DUAN Lijun1 NIU Yun1 SUN Qiujie4 ZHOU Hao5. Correlation research of neck circumference and benign prostatic hyperplasia in type 2 diabetic mellitus patients. 中国医药导报, 2020, 17(6): 77-80.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I6/77

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