间充质干细胞的功能特点及治疗类风湿关节炎的相关研究进展

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摘要间充质干细胞（MSCs）具有自我更新能力和多向分化潜能，在免疫调节、控制炎症和修复软骨破坏等方面有重要作用。MSCs产生大量可溶性膜结合因子，其中一些可抑制免疫应答，诱导免疫耐受，发挥重要的免疫调节作用。由于MSCs的生物学特性和免疫调节作用，在动物试验和临床研究中均证实了MSCs治疗类风湿关节炎的有效性与安全性。本文针对MSCs的功能特点和治疗类风湿关节炎方面的相关研究进展进行简要综述。

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	达古拉1 谢先达2▲ 王静1▲

关键词 ：间充质干细胞, 类风湿关节炎, 治疗, 免疫调节

Abstract：Mesenchymal stem cells (MSCs) have self-renewal ability and multi-directional differentiation potential, and they play an important role in immune regulation, inflammation control and cartilage destruction. MSCs produce a large number of soluble membrane-binding factors, some of which inhibit immune responses, induce immune tolerance, and exert important immunomodulatory effects. Due to the biological characteristics and immunomodulatory effects of MSCs, the efficacy and safety of MSCs in the treatment of rheumatoid arthritis have been confirmed in animal experiments and clinical studies in recent years. This article briefly reviews the functional characteristics of MSCs and the related research progress in the treatment of rheumatoid arthritis.

Key words： Mesenchymal stem cells Rheumatoid arthritis Treatment Immune regulation

基金资助:内蒙古医科大学青年创新基金项目（YKD2017Q NCX060）；
内蒙古自然科学基金项目（2018LH08041）；
内蒙古医科大学科技百万工程（联合）项目[YKD2017KJBW（LH）001]；
《临床免疫学检验技术》本科教学改进的规划和实践（NYJXGG 2018053）。

通讯作者: ▲共同通讯作者

引用本文:

达古拉1 谢先达2▲ 王静1▲. 间充质干细胞的功能特点及治疗类风湿关节炎的相关研究进展[J]. 中国医药导报, 2020, 17(6): 40-42.
DA Gula1 XIE Xianda2▲ WANG Jing1▲. Research progress of the functional characteristics and the treatment of rheumatoid arthritis of mesenchymal stem cells. 中国医药导报, 2020, 17(6): 40-42.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I6/40

[1] Zeng QY，Chen R，Darmawan J，et al. Rheumatic diseases in China [J]. Arthritis Res Ther，2008，10（1）：R17.
[2] Pistoia V，Raffaghello L. Mesenchymal stromal cells and autoimmunity [J]. Int Immunol，2017，29（2）：49-58.
[3] Urban VS，Kiss J，Kovacs J，et al. Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes [J]. Stem Cells，2008，26（1）：244-253.
[4] da Silva Meirelles L，Chagastelles PC，Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues [J]. J Cell Sci，2006，119（Pt11）：2204-2213.
[5] de Bari C. Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys? [J]. Arthritis Res Ther，2015， 17：113.
[6] Le Blanc K，Rasmusson I，Sundberg B，et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells [J]. Lancet，2004， 363（9419）：1439-1441.
[7] Cras A，Farge D，Carmoi T，et al. Update on mesenchymal stem cell-based therapy in lupus and scleroderma [J]. Arthritis Res Ther，2015，17：301.
[8] DI Nicola M，Carlo-Stella C，Magni M，et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli [J]. Blood，2002，99（10）：3838-3843.
[9] Krampera M，Glennie S，Dyson J，et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide [J]. Blood，2003，101（9）：3722-3729.
[10] Gao F，Chiu SM，Motan DA，et al. Mesenchymal stem cells and immunomodulation：current status and future pros-pects [J]. Cell Death Dis，2016，7：e2062.
[11] Caprnda M，Kubatka P，Gazdikova K，et al. Immunomodulatory effects of stem cells：Therapeutic option for neurodegenerative disorders [J]. Biomed Pharmacother，2017， 91：60-69.
[12] Corcione A，Benvenuto F，Ferretti E，et al. Human mesenchymal stem cells modulate B-cell functions [J]. Blood，2006，107（1）：367-372.
[13] Ciccocioppo R，Cangemi GC，Kruzliak P，et al. Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn′s disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact [J]. Stem Cell Res Ther，2015，6：137.
[14] Gimeno ML，Fuertes F，Barcala Tabarrozzi AE，et al. Pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells have Immunomodulatory Capacity Mediated by Transforming Growth Factor-β1 [J]. Stem Cells Transl Med，2017，6（1）：161-173.
[15] Saldanha-Araujo F，Haddad R，Farias KC，et al. Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes：roles of canonical and non-canonical NF-κB signalling [J]. J Cell Mol Med，2012，16（6）：1232-1244.
[16] Augello A，Tasso R，Negrini SM，et al. Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis [J]. Arthritis Rheum，2007，56（4）：1175-1186.
[17] Sonomoto K，Yamaoka K，Oshita K，et al. Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway [J]. Arthritis Rheum，2012， 64（10）：3355-3363.
[18] Fukuyo S，Yamaoka K，Sonomoto K，et al. IL-6-accelerated calcification by induction of ROR2 in human adipose tissue-derived mesenchymal stem cells is STAT3 dependent [J]. Rheumatology（Oxford，England），2014，53（7）：1282-1290.
[19] Choi JR，Yong KW，Choi JY. Effects of mechanical loading on human mesenchymal stem cells for cartilage tissue engineering [J]. J Cell Physiol，2018，233（3）：1913-1928.
[20] Tanaka Y. Human mesenchymal stem cells as a tool for joint repair in rheumatoid arthritis [J]. Clin Exp Rheumatol，33（4 Suppl 92）：S58-S62.
[21] Yan X，Cen Y，Wang Q. Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expression [J]. Sci Rep，2016，6：28915.
[22] Shin TH，Kim HS，Kang TW，et al. Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis [J]. Cell Death Dis，2016，7（12）：e2524.
[23] Zhang X，Yamaoka K，Sonomoto K，et al. Local delivery of mesenchymal stem cells with poly-lactic-co-glycolic acid nano-fiber scaffold suppress arthritis in rats [J]. PLoS ONE，2014，9（12）：e114621.
[24] Contreras RA，Figueroa FE，Djouad F，et al. Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression [J]. Stem Cells Int，2016，2016：3162743.
[25] Wang L，Wang L，Cong X，et al. Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis：safety and efficacy [J]. Stem Cells Dev，2013，22（24）：3192-3202.
[26] Sun Y，Deng W，Geng L，et al. Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells [J]. J Immunol Res，2015，2015：284215.
[27] Alvaro-Gracia JM，Jover JA，Garcia-Vicuna R，et al. Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis （Cx611）：results of a multicentre，dose escalation，randomised，single-blind，placebo-controlled phase Ib/IIa clinical trial [J]. Ann Rheum Dis，2017，76（1）：196-202.
[28] Cosenza S，Toupet K，Maumus M，et al. Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis [J]. Theranostics，2018，8（5）：1399-1410.
[29] Li T，Xia M，Gao Y，et al. Human umbilical cord mesenchymal stem cells：an overview of their potential in cell-based therapy [J]. Expert Opin Biol Ther，2015，15（9）：1293-1306.