胶质母细胞瘤的生物标志物研究进展

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摘要胶质母细胞瘤（GBM）的生物标志物在疾病诊断、疗效预测和预后等方面发挥重要作用。GBM的生物标志物有以下4类：经典标志物、循环标志物、基因标签和其他。鉴于GBM的高度侵袭性和复杂性，临床上迫切需要深入研究可用于预后和预测的非侵入性生物标志物，尤其是可用于早期诊断的标志物。

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	熊中奎1 郎娟2 王思本1

关键词 ：胶质母细胞瘤, 生物标志物, 表皮生长因子受体变体Ⅲ, 1p/19q共缺失, 异柠檬酸脱氢酶突变, O6-甲基鸟嘌呤-DNA 甲基转移酶甲基化

Abstract：Biomarkers of Glioblastoma multiforme (GBM) plays an important role in disease diagnosis, efficacy prediction and prognosis. There are four types of biomarkers for GBM: classical biomarkers, circulating biomarkers, gene tags and others. In view of the high invasiveness and complexity of GBM, there is an urgent to conduct in-depth clinical studies on non-invasive biomarkers that can be used for prognosis and prediction, especially for early diagnosis.

Key words： Glioblastoma multiforme Biomarker Epidermal growth factor receptor variantⅢ 1p/19q codeletion Isocitrate dehydrogenase mutation O6-methylguanine-DNA methyltransferase methylation

基金资助:浙江省基础公益技术应用研究计划项目（LGF1 9H160016）；
浙江省医坛新秀培养工程（浙卫发[2015]70号）；
浙江省绍兴第二医院青蓝人才培训工程（绍二医发[2016]61号）；
浙江省医药卫生科技计划项目（2017KY677、2019KY730）。

作者简介: 熊中奎（1976.3-），男，博士，副主任医师；研究方向：放射肿瘤学临床与基础研究。

引用本文:

熊中奎1 郎娟2 王思本1. 胶质母细胞瘤的生物标志物研究进展[J]. 中国医药导报, 2020, 17(4): 55-58.
XIONG Zhongkui1 LANG Juan2 WANG Siben1. Research progresses of biomarkers of glioblastoma multiforme. 中国医药导报, 2020, 17(4): 55-58.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I4/55

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