人乳头瘤病毒感染与生殖器病变关系的研究进展

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摘要人乳头瘤病毒（HPV）根据致病性可分为高危型和低危型。高危型主要导致女性宫颈癌和男性阴茎癌，低危型主要引起生殖器疣。不同基因型所致疾病类型有一定的差异，女性鳞癌以HPV-16为主要型别；女性腺癌和腺鳞癌以HPV-18为主；男性阴茎癌以HPV-16、HPV-18感染为主；女性生殖器疣和男性生殖器疣、不孕症以HPV-6、HPV-11为主要型别。目前市场上针对HPV有预防性和治疗性两种疫苗，不同人群应有针对性地合理选择疫苗，对预防和清除HPV至关重要。

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	张仕华孙辉杜彦丹▲

关键词 ：人乳头瘤病毒感染, 生殖系统肿瘤, 生殖器疣, 亚型

Abstract：Human papillomavirus (HPV) can be divided into high-risk type and low-risk type according to pathogenicity. The high-risk type mainly causes cervical cancer in women and the penis cancer in men, while the low-risk type mainly causes genital warts. Different genotypes cause certain differences in disease types. HPV-16 is the main type of female squamous cell carcinoma; HPV-18 is the main type of female adenocarcinoma and adenosquamous carcinoma; HPV-16 and HPV-18 infection are the main types of male penile cancer; the main types of female genital warts and male genital warts and infertility are HPV-6 and HPV-11. Currently, there are two preventive and therapeutic vaccines for HPV on the market. Different populations should choose vaccines in a targeted and reasonable manner, which is essential for preventing and eliminating HPV.

Key words： Human papillomavirus infection Reproductive system tumors Genital warts Subtypes

基金资助:内蒙古自治区卫生计生科研计划项目（2017031 92）；
内蒙古民族大学国家基金培育项目（NMDGP17 108）。

通讯作者: ▲通讯作者

作者简介: 张仕华（1990.9-），女，硕士，主要从事临床检验诊断研究。

引用本文:

张仕华孙辉杜彦丹▲. 人乳头瘤病毒感染与生殖器病变关系的研究进展[J]. 中国医药导报, 2020, 17(4): 48-51.
ZHANG Shihua SUN Hui DU Yandan▲. Advancesin research on the relationship between human papilloma-virus infection and genital lesions. 中国医药导报, 2020, 17(4): 48-51.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I4/48

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