乳腺癌胃转移1例

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摘要乳腺癌是女性最常见的恶性肿瘤之一，早期乳腺癌多不具备典型的症状和体征，通常是由体检或筛查发现后通过细胞或组织病理学明确诊断，并采用手术、放化疗、靶向及内分泌治疗等方法进行综合治疗，其预后受病理类型、疾病分期、分子标志物等多种因素影响。尽管早期乳腺癌经综合治疗后已成为治疗效果最佳的实体肿瘤之一，一旦出现复发转移其生存时间仍将迅速缩短。乳腺癌常见转移部位为骨骼、淋巴结、软组织及肺、脑、肝等，以胃为首发转移部位相对罕见且其临床、影像学及胃镜表现均缺乏特异性，与原发性胃癌鉴别困难。本文将报道1例乳腺浸润性小叶癌转移至胃的患者，并结合文献分析该疾病的临床特征、诊断、治疗方法及预后，以提高临床对乳腺癌胃转移的认识。

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	吕灵艳1 王秀红2 万冬桂3

关键词 ：乳腺癌, 胃转移癌, 诊断, 病例报告

Abstract：Breast cancer is one of the most common malignant tumors in women. Most early breast cancer do not have typical symptoms and signs. Cell or histopathology is used diagnose the disease after physical examination or screening and treated by comprehensive treatment methods such as surgery, chemoradiotherapy, targeting and endocrine therapy. The prognosis of breast cancer is affected by many factors, for example pathological type, stage of disease, molecular markers, and so on. Although early breast cancer has become one of the most effective solid tumors after comprehensive treatment, the survival time will be shortened rapidly once recurrence and metastasis occur. The common metastatic sites are bone, lymph node, soft tissue, lung, brain, liver, and so on. The gastric as the first site of metastasis is relatively rare and the clinical, imaging and endoscopic manifestations are lack of specificity, making it difficult to differentiate from primary gastric cancer. This paper reports a case of invasive lobular breast carcinoma with gastric metastasis and analyzes the clinical characteristics, diagnosis, treatment and prognosis of the disease combined with the literature, in order to improve the clinical understanding of gastric metastasis from breast cancer.

Key words： Breast cancer Gastric metastasis Diagnosis Case report

基金资助:北京市科学技术委员会重大项目（D1611000051 16005）。

通讯作者: 万冬桂（1964.10-），女，硕士，主任医师；研究方向：中西医结合防治肿瘤。

作者简介: 吕灵艳（1995.1-），女，北京中医药大学中日友好医院临床医学院2017级中西医结合临床专业在读硕士研究生；研究方向：中西医结合防治肿瘤。

引用本文:

吕灵艳1 王秀红2 万冬桂3. 乳腺癌胃转移1例[J]. 中国医药导报, 2019, 16(36): 157-159,164.
LYU Lingyan1 WANG Xiuhong2 WAN Donggui3. One case of gastric metastasis from breast cancer. 中国医药导报, 2019, 16(36): 157-159,164.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I36/157

[1] 郑荣寿，孙可欣，张思维，等.2015年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志，2019，41（1）：19-28.
[2] Xu L，Ling S，Yan N，et al. Metastatic gastric cancer from breast carcinoma：A report of 78 cases [J]. Oncol Lett，2017，14（4）：4069-4077.
[3] Bray F，Ferlay J，Soeriomataram I，et al. Global Cancer Statistics 2018：GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [J]. CA Cancer J Clin，2018，68（6）：394-424.
[4] Balakrishnan B，Shaik S，Burman-Solovyeva I. An Unusual Clinical Presentation of Gastrointestinal Metastasis from Invasive Lobular Carcinoma of Breast [J]. J Investig Med High Impact Case Rep，2016，4（2）：232 4709 616 639 723.
[5] McLemore EC，Pockaj BA，Reynolds C，et al. Breast cancer：presentation and intervention in women with gastrointestinal metastasis and carcinomatosis [J]. Ann Surg Oncol，2005，12（11）：886-894.
[6] Arrangoiz R，Papavasiliou P，Dushkin H，et al. Case report and literature review：Metastatic lobular carcinoma of the breast an unusual presentation [J]. Int J Surg Case Rep，2011，2（8）：301-305.
[7] Benfiguig A，Anciaux ML，Eugène CI，et al. Gastric metastasis of breast cancer occurring after a cancer-free interval of 30 years [J]. Ann Gastroenterol Hepatol（Paris），1992，28（4）：175-177.
[8] Kim DH，Son SM，Choi YJ，et al. Gastric metastasis from invasive lobular breast cancer，mimicking primary gastric cancer：A case report [J]. Medicine（Baltimore），2018，97（13）：e0 258.
[9] 杨丽，时高峰，周涛，等，非直接侵犯性胃转移癌的多层螺旋CT特征：5例病例报告并文献复习[J].世界华人消化杂志，2015，23（28）：4606-4610.
[10] 高福平，邢一鸣，薛松，等，胃转移性乳腺癌临床病理观察[J].诊断病理学杂志，2018，25（4）：278-280.
[11] 王一同，张振华，卢雯平，等.中医体质学在乳腺癌防治中的应用价值[J].中国医药，2017，12（6）：901-904.
[12] 杜岚，杨敬春，常莹，等.标准乳腺MRI与腋窝超声鉴别乳腺癌有无转移及晚期腋窝淋巴结病变的差异[J].中国医药导报，2017，14（35）：168-171.
[13] 李登华.MRI相比CT在诊断乳腺癌方面的优势分析[J].中国现代医生，2017，55(27)：102-104，108，封3.
[14] Qu Q，Zong Y，Fei XC，et al. The importance of biopsy in clinically diagnosed metastatic lesions in patients with breast cancer [J]. World J Surg Oncol，2014，12（1）：93-99.
[15] Sato T，Muto I，Fushiki M，et al. Metastatic breast cancer from gastric and ovarian cancer，mimicking inflammatory breast cancer：report of two cases [J]. Breast Cancer，2008，15（4）：315-320.
[16] Ordóñez NG. Value of GATA3 immunostaining in tumor diagnosis：a review [J]. Adv Anat Pathol，2013，20（5）：352-360.
[17] Miettinen M，McCue PA，Sarlomo-Rikala M，et al. GATA3：a multispecific but potentially useful marker in surgical pathology：a systematic analysis of 2500 epithelial and nonepithelial tumors [J]. Am J Surg Pathol，2014， 38（1）：13-22.
[18] Asch-Kendrick R，Cimino-Mathews A. The role of GATA3 in breast carcinomas：a review [J]. Hum Pathol，2016，48（2）：37-47.
[19] Sangoi AR，Shrestha B，Yang G，et al. The novel marker GATA3 is significantly more sensitive than traditional markers mammaglobin and GCDFP15 for identifying breast Cancer in surgical and cytology specimens of metastatic and matched primary tumors [J]. Appl Immunohistochem Mol Morphol，2016，24（4）：229-237.
[20] Gown AM，Fulton RS，Kandalaft PL. Markers of metastatic carcinoma of breast origin [J]. Histopathology，2016，68（1）：86-95.
[21] Gadde R，Tamariz L，Hanna M，et al. Metastatic gastric cancer（MGC）patients：Can we improve survival by metastasectomy? A systematic review and meta-analysis [J]. J Surg Oncol，2015，112（1）：38-45.
[22] Kliiger J，Gorbaty M. Metastasis to the pancreas and stomach from a breast cancer primary：a case report [J]. J Community Hosp Intern Med Perspect，2017，7（4）：234-237.
[23] Jucá PCFC，Corrêa S，Vignal GM，et al. HNF4A expression as a potential diagnostic tool to discriminate primary gastric cancer from breast cancer metastasis in a Brazilian cohort [J]. Diagn Pathol，2017，12（1）：43-50.
[24] Woo J，Lee JH，Lee KE，et al. Gastric Metastasis as the First Presentation One Year Before Diagnosis of Primary Breast Cancer [J]. Am J Case Rep，2018，26（19）：354-359.