血清C1q、超敏C反应蛋白与冠状动脉粥样硬化性心脏病的相关性研究

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摘要目的探讨血清C1q、超敏CRP（hs-CRP）水平与冠状动脉粥样硬化性心脏病（CHD）的相关性。方法回顾性分析2016年10月～2017年4月在湖北医药学院附属东风总医院心内科406例患者的临床资料，根据是否有冠状动脉介入手术史或冠脉造影检查发现冠脉狭窄程度是否≥50%分为对照组（200例）和冠心病组（206例）。比较两组患者C1q、hs-CRP水平。采用Logistic回归分析对CHD的危险因素进行分析。结果冠心病组血清C1q水平低于对照组，血清hs-CRP水平高于对照组，差异有统计学意义（P ＜ 0.05）。Logistic多因素回归分析显示，年龄（OR = 1.036，95% CI =1.009～1.064，P ＜ 0.05）、糖尿病（OR = 4.629，95% CI = 2.159～9.924，P ＜ 0.05）、LDL-C（OR = 2.965，95%CI = 1.286～6.835，P ＜ 0.05），Glu（OR = 1.033，95% CI = 1.246～1.856，P ＜ 0.05），hs-CRP（OR = 1.509， 95% CI = 1.225～1.859，P ＜ 0.05）是CHD的危险因素，C1q（OR = 0.991，95% CI = 0.983～0.998，P ＜ 0.05）是CHD的保护因素。结论血清C1q是CHD的保护因素，hs-CRP是CHD的危险因素，二者可以作为临床上较可靠的CHD诊断、评估预测指标。

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	陈孝强杨汉东陈俊

关键词 ：冠状动脉粥样硬化性心脏病, 血清C1q, 超敏C反应蛋白

Abstract：Objective To explore the correlation between serum C1q, hypersensitive C-reactive protein(hs-CRP) and coronary atherosclerotic heart disease(CHD). Methods From October 2016 to April 2017, 406 clinical data of patients treated in the Department of Cardiology, Dongfeng General Hospital, Hubei University of Medicine were analyzed retrospectively and divided into the control group (200 cases) and the CHD group (206 cases) according to the history of percutaneous coronary intervention coronary angiography or whether the coronary artery stenosis was greater than 50% by coronary angiography. The levels of C1q and hs-CRP were compared between the two groups. The risk factors of CHD were analyzed by Logistic regression analysis. Results The serum C1q in the CHD group was lower than that of control group, and the hs-CRP in the CHD group was higher than that of control group, with statistically significant differences (P ＜ 0.05). Logistic regression analysis indicated that in the coronary heart disease group the age (OR = 1.036, 95%CI =1.009-1.064, P ＜ 0.05), diabetes (OR = 4.629, 95%CI = 2.159-9.924, P ＜ 0.05), LDL-C (OR = 2.965, 95%CI = 1.286-6.835, P ＜ 0.05), Glu (OR = 1.033, 95%CI = 1.246-1.856, P ＜ 0.05), hs-CRP (OR = 1.509, 95%CI = 1.225-1.859, P ＜ 0.05) were the risk factors for CHD and the C1q (OR = 0.991，95%CI = 0.983-0.998，P ＜ 0.05) was the protective factor. Conclusion Serum C1q is the protective factor and hs-CRP is the risk factor in CHD and both can be used as clinically reliable diagnosis and evaluation index for CHD.

Key words： Coronary heart disease Serum C1q Hypersensitive C-reactive protein

基金资助:国家自然科学基金资助项目（81400288、815 73244）；
湖北省科技计划项目（2016CFB529）。

通讯作者: 杨汉东（1962.5-），男，博士，主任医师，湖北医药学院附属东风总医院心血管内科主任，主要从事心血管流行病学研究。陈俊（1985.9-），男，硕士，主要从事心血管免疫研究。

引用本文:

陈孝强杨汉东陈俊. 血清C1q、超敏C反应蛋白与冠状动脉粥样硬化性心脏病的相关性研究[J]. 中国医药导报, 2017, 14(35): 41-44,49.
CHEN Xiaoqiang YANG Handong CHEN Jun. The correlation study between serum C1q, high sensitivity C-reactive protein and coronary atherosclerotic heart disease. 中国医药导报, 2017, 14(35): 41-44,49.

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