Clinical effect of Wuling Capsules combined with Fluoxetine Capsules in the treatment of type 2 diabetes mellitus with heart-kidney disharmony and emotional handicap
LIU Yan1 LI Yue2 LIU Yi2 WANG Huiying2
1.Department of Traditional Chinese Medicine, Aerospace Center Hospital, Beijing 100039, China;
2.Community Center, Aerospace Center Hospital, Beijing 100039, China
Abstract：Objective To explore clinical effect of Wuling Capsules combined with Fluoxetine Capsules in the treatment of type 2 diabetes mellitus with heart-kidney disharmony and emotional handicap. Methods One hundred and three type 2 diabetes mellitus patients with heart-kidney disharmony and emotional handicap in Aerospace Center Hospital from May 2017 to December 2018 were selected for the study. The patients were divided into control group (n = 51) and treatment group (n = 52) according to random number table method. Both groups received routine glycemic control therapy. Fluoxetine Hydrochloride Capsules were taken orally in control group. Wuling Capsules were taken orally in treatment group on the basis of control group. Patients in both groups received continuous treatment for 12 weeks. Clinical efficacy, Hamilton depression rating scale (HDRS-17) score, traditional Chinese medicine syndrome score, blood glucose level, HOMA-IR and adverse reactions were compared between two groups. Results Total clinical effective rate of treatment group was significantly higher than that of control group (P < 0.05). After treatment, HDRS-17 score and traditional Chinese medicine syndrome score of two groups were lower than those before treatment, and those in treatment group were lower than those in control group (P < 0.05). After treatment, fasting blood-glucose, glycated albumin and HOMA-IR in two groups were lower than those before treatment, and those in treatment group were lower than those in control group (P < 0.05). There was no significant difference in incidence of adverse reactions between two groups (P > 0.05). Conclusion Wuling Capsules combined with Fluoxetine Capsules has obvious effect and high safety in the treatment of type 2 diabetes mellitus with heart-kidney disharmony and emotional handicap. It can also effectively reduce the degree of depression of patients, improve the level of blood glucose and insulin resistance, which is worthy of clinical attention.
刘焱1 李月2 刘怡2 王会颖2. 乌灵胶囊联合氟西汀胶囊治疗心肾不交型2型糖尿病伴情绪障碍的临床效果[J]. 中国医药导报, 2019, 16(34): 122-125.
LIU Yan1 LI Yue2 LIU Yi2 WANG Huiying2. Clinical effect of Wuling Capsules combined with Fluoxetine Capsules in the treatment of type 2 diabetes mellitus with heart-kidney disharmony and emotional handicap. 中国医药导报, 2019, 16(34): 122-125.
[1] Yang W，Lu J，Weng J，et al. Prevalence of diabetes among men and women in China [J]. N Engl J Med，2010， 362（12）：1090-1101.
[2] 中国2型糖尿病防治指南（2017年版）[J].中国实用内科杂志，2018，38（4）：292-344.
[3] Shi Z. Prevalence of diabetes among men and women in China [J]. N Engl J Med，2010，362（25）：2425.
[4] 唐小妹.乌灵胶囊治疗2型糖尿病合并抑郁（心肾不交证）的临床疗效评估[D].成都：成都中医药大学，2017.
[5] World Health Organization. Definition，diagnosis and claasification of diabetes mellitus and its complications [R]. Geneva：WHO，1999.
[6] 中华医学会精神病学分会.中国精神障碍分类与诊断标准第三版（精神障碍分类）[J].中华精神科杂志，2001，34（3）：184-188.
[7] 张伯臾.中医内科学[M].上海：上海科学技术出版社，1985：233-236．
[8] 高仲录，索江海，郑万利.乌灵胶囊联合圣约翰草提取物片治疗脑梗死后抑郁的临床研究[J].现代药物与临床，2018，33（12）：64-68.
[9] 危北海，陈治水，张万岱.胃肠疾病中医证候评分表[J].世界华人消化杂志，2004，12（11）：2701-2703.
[10] 佚名.针灸对2型糖尿病患者情绪障碍及糖代谢的干预作用[J].湖北中医杂志，2018，40（10）：32-34.
[11] 唐启盛，曲淼，包祖晓，等.抑郁症中医证候规律及诊疗标准制定的研究[J].北京中医药大学学报，2011，34（2）：77-81.
[12] 徐雅斐.乌灵胶囊与氟西汀联用治疗产后抑郁疗效观察[J].医药论坛杂志，2016，37（11）：72-73.
[13] 王剑.乌灵胶囊对脑卒中后抑郁患者血清Hcy、神经细胞因子、单胺类递质代谢和炎症反应的影响[J].陕西中医，2018，39（10）：1357-1359.
[14] 陈永新，李涛，韩亚琼，等.乌灵胶囊联合米氮平对更年期抑郁症患者神经内分泌的影响[J].中药药理与临床，2017，33（2）：200-203.
[15] 刘玉亭，曹博群，贾晨，等.乌灵胶囊对丙戊酸钠治疗戊四唑诱导癫痫大鼠致肝损伤的影响[J].华西药学杂志，2018，33（1）：34-36.
[16] 邹小冬，张震中，程有根，等.乌灵胶囊对小鼠认知功能的影响[J].中国临床药理学杂志，2018，34（20）：2421-2423.
[17] 师林，柯斌.乌灵胶囊对2型糖尿病伴失眠症患者PSQI量表及血糖的影响[J].广东医学，2012，33（10）：1491-1493.
[18] 邢茂娟，袁志刚，张海文，等.内脂素、肿瘤坏死因子α与2型糖尿病合并代谢综合征的相关研究[J].临床和实验医学杂志，2013，12（1）：4-6.
[19] 谢燕，高智玉，王雪花，等.乌灵胶囊治疗帕金森病伴抑郁的临床研究[J].中国临床药理学杂志，2017，33（11）：980-982.
[20] 刘凤丽，李焰，焦丽艳，等.乌灵胶囊抗脑卒中后疲劳患者炎症反应的作用[J].中国老年学杂志，2017，37（7）：1725-1727.
2019, Vol. 16 
京公网安备 11010502046598号