Analysis of correlation between depression and motor dysfunction in Parkinson′s disease
WANG Xuemei1 FENG Tao1 CHEN Huimin1 GU Zhuqin2 CHEN Biao2
1.Department of Neurodegenerative Disease, Centre of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; 2.Department of Neurology, Beijing Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Abstract：Objective To investigate the correlation between depression and motor dysfunction in patients with Parkinson′s disease (PD). Methods A retrospective case-control study was adopted in this study. 800 PD patients in neurology clinic were enrolled in Beijing Tiantan Hospital from April 2008 to August 2015. All patients were assessed with Center for Epidemiologic Studies Depression Scale (CES-D) and divided into the depression group and the non-depression group. The two groups were compared with general data on demographics, unified Parkinson′s disease rating scale (UPDRS), Hoehn-Yahr stage and mini-mental state examination (MMSE) scores respectively. The Spearman rank correlation coefficient was used to analyze the correlation between depression and motor dysfunction. Logistic regression was applied to explore risk factors of PD depression. Results 362 cases (45.3%) were identified as suffering from depression. In the depression group, the proportion of patients with Hoehn-Yahr stage greater than 2.5 was higher than that of the non-depression group (PD). The UPDRS part Ⅲ scores, the UPDRS scores of rigidity items, tremor items and bradykinesia items of the depression group were significantly higher than those of the non-depression group (P < 0.01). There was significant correlation between CES-D scores and UPDRS motor scores (r=0.405, P < 0.01). Logistic regression analysis showed: female, higher score in UPDRS partⅠ/Ⅱ, gait and posture disturbance, faster progression of motor symptoms were risk factors of PD depression (P < 0.05). Conclusion Depression is one of the common symptoms of PD and correlates with motor dysfunction.
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2017, Vol. 14 
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