甲状腺良恶性结节在超声造影下的定量分析

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摘要目的探讨甲状腺良恶性结节在超声造影下的定量分析。方法选取2016年10月~2018年12月在上海市宝山区中西医结合医院拟进行手术的甲状腺结节患者60例，共62个结节，且所有病例均取得明确的病理结果。所有患者行超声造影检查并对甲状腺结节及周围正常组织的时间-强度曲线（TIC）参数进行定量分析，记录峰值强度差（ΔPI）、斜率差（ΔSlope）、曲线下面积差（ΔAUC），绘制ROC曲线，评价各参数对甲状腺良恶性结节的鉴别诊断价值。结果当ΔPI、ΔSlope、ΔAUC在甲状腺良恶性结节鉴别诊断中的截断值分别为-3.25、-1.27、-89.65时，其敏感度分别为83%、75%、75%，特异度分别为72%、57%、77%。结论对超声造影中TIC曲线各参数的定量分析可能有助于对其甲状腺良恶性结节的鉴别诊断。

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	陈捷1 郑丽1 王媚瑜1 周大为1 杜晶2 江鑫辉1 忻俊1

关键词 ：超声造影, 时间-强度曲线, 甲状腺结节

Abstract：Objective To explore the quantitative analysis of benign and malignant thyroid nodules under contrast-enhanced ultrasound. Methods From October 2016 to December 2018, 60 patients with a total of 62 thyroid nodules who proposed to be operated on Shanghai Baoshan District Hospital of Traditional Chinese and Western Medicine were selected, and all patients obtained definite pathological results. All patients were treated with contrast-enhanced ultrasound examination and time-intensity curve (TIC) parameters in thyroid nodules and surrounding normal tissues were quantitatively analysed. The difference of peak intensity (ΔPI), the difference of Slope (ΔSlope) and the difference of area under the curve (ΔAUC) were recorded. The ROC curve were drew to evaluate the value of differential diagnosis of benign and malignant thyroid nodules. Results When the cut-off values of ΔPI, ΔSlope and ΔAUC in differential diagnosis of benign and malignant thyroid nodules were -3.25, -1.27, -89.65, the sensitivity were 83%, 75%, 75% and the specificity were 72%, 57%, 77%, respectively. Conclusion Quantitative analysis of TIC curve parameters in contrast-enhanced ultrasound may be helpful in differential diagnosis of benign and malignant thyroid nodules.

Key words： Contrast-enhanced ultrasound Time-intensity curve Thyroid nodule

基金资助:上海市科学技术委员会科研计划项目（1641196 8800）；
上海市宝山区科学技术委员会科技创新项目（17-E-14）。

通讯作者: 郑丽（1966-），女，硕士，主任医师，主要从事临床超声诊断工作。

引用本文:

陈捷1 郑丽1 王媚瑜1 周大为1 杜晶2 江鑫辉1 忻俊1. 甲状腺良恶性结节在超声造影下的定量分析[J]. 中国医药导报, 2019, 16(31): 141-143,147.
CHEN Jie1 ZHENG Li1 WANG Meiyu1 ZHOU Dawei1 DU Jing2 JIANG Xinhui1 XIN Jun1. Quantitative analysis of benign and malignant thyroid nodules under contrast-enhanced ultrasound. 中国医药导报, 2019, 16(31): 141-143,147.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I31/141

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