Influence of Bushen Huoxue Decoction on HOXA10 expression in uterine flushing fluid of patients with endometriosis-related infertility
LIU Kaili1 TANG Weiwei2 WAN Guiping2
1.Graduate School，Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210023, China;
2.Department of Obstetrics and Gynecology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210028, China
Abstract：Objective To investigate the changes of HOXA10 in uterine flushing fluid after treatment with Bushen Huoxue Decoction in patients with endometriosis (EMs) caused by kidney-deficiency and blood stasis type EMs-related infertility. Methods From December 2016 to June 2018, 20 cases who diagnosed EMs-related infertility as kidney deficiency and blood stasis in the Department of Gynecology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine were selected. They were treated with Bushen Huoxue Decoction for three menstrual cycles. The endometrial thickness of the implantation window and blood flow parameters were evaluated by transvaginal Doppler ultrasound before and after treatment. The concentrations of HOXA10 in uterine flushing fluid of before and after treatment were analyzed by enzyme liked imrnunosorbent assay. Results After Bushen Huoxue Decoction treatment, the thickness of the implantation window endometria was obviously higher than that before treatment, blood flow parameters of Uterine artery resistance index (PI) and pulsatility index (RI) were decreased significantly, the expression level of HOXA10 was significantly higher than that before treatment, and the differences were statistically significant (P < 0.05). Condusion Bushen Huoxue Decoction can increase the thickness of endometrium, improve the intrauterine hemodynamic parameters of patients with EMs-related infertility caused by kidney deficiency and blood stasis, improve the expression level of HOXA10 in uterine flushing fluid and improve endometrial receptivity.
刘凯丽1 汤伟伟2 万贵平2. 补肾活血汤对子宫内膜异位症相关性不孕患者宫腔冲洗液中HOXA10表达水平的影响[J]. 中国医药导报, 2019, 16(30): 97-100.
LIU Kaili1 TANG Weiwei2 WAN Guiping2. Influence of Bushen Huoxue Decoction on HOXA10 expression in uterine flushing fluid of patients with endometriosis-related infertility. 中国医药导报, 2019, 16(30): 97-100.
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2019, Vol. 16 
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