Abstract：The researchers aim to develop new technologies and new drugs, hoping to improve cerebral ischemia related symptoms by extending the therapeutic time window, promoting neurogenesis and reducing neuroinflammation. In recent years, although academic-industrial collaborations have invested a lot in the field of stroke, no breakthrough has been achieved in translational medicine, suggesting that a deeper understanding of the pathogenesis of cerebral ischemia is required. In physiological state, microglial plays an important regulatory role in monitoring microenvironment in brain, promoting synaptic development, maintaining normal synaptic function and maintaining neuroplasticity. Cerebral ischemia can lead to microglia polarization. The regulation of the dual function of injury and repair after microglial neuronal polarization are considered an important target for brain protection therapy, and related drugs have shown considerable neuroprotective effect in animal experiments. In this review, the characteristics and regulations of microglia polarization after cerebral ischemia and related drug development are comprehensively reviewed.
杨程显 包新杰 王任直. 小胶质细胞极化在脑缺血中的研究进展[J]. 中国医药导报, 2019, 16(30): 34-37.
YANG Chengxian BAO Xinjie WANG Renzhi. Research progress of microglia polarization in ischemic stroke. 中国医药导报, 2019, 16(30): 34-37.
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2019, Vol. 16 
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