1.Institute of Pharmacy and Pharmacology, University of South China, Hu′nan Province, Hengyang 421001, China;
2.Hu′nan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System, Hu′nan University of Medicine, Hu′nan Province, Huaihua 418000, China; 3.Department of Pharmacy, the First Affiliated Hospital of Hu′nan University of Medicine, Hu′nan Province, Huaihua 418000, China
Abstract：Pemetrexed (PEM) is a new generation of anti-tumor drug that blocks multiple targets of folate metabolism pathway, and it is more effective than other traditional anti-folate drugs. However, due to the lack of tumor specificity and dose-dependent toxicity, its clinical application is limited. Nanocarriers have attracted wide attention because of their unique advantages in reducing toxicity and improving therapeutic effect. In recent years, studies on PEM nanoparticles, including liposomes, nanoparticles, micelles, nanoemulsions and hydrogels, have made some progress in improving the solubility of PEM, prolonging the circulation time in vivo, improving targeting, reducing adverse reactions and enhancing anti-tumor activity, and different drug delivery methods have been developed. This paper reviews the research progress of PEM nanopreparation, and provides the theoretical basis for the development and application of new PEM nanopreparation.
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2019, Vol. 16 
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