社区高血压患者血尿酸水平与24 h血压变异性的相关性研究

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摘要目的研究北京市东城区交东社区原发性高血压患者的血尿酸（BUA）水平与24 h动态血压变异性的关系及临床意义。方法回顾性分析2015年1月~2016年12月交东社区126例原发性高血压患者的BUA、血脂、血糖等资料，依据BUA水平分为三组：A组44例，BUA为250~＜350 μmol/L；B组42例，BUA为350~＜450 μmol/L；C组40例，BUA为450~550 μmol/L。采用Pearson相关法分析BUA水平与血压变异的相关性。结果三组24 h收缩压变异系数（24 h SCV）、日间收缩压变异系数（dSCV）、夜间收缩压变异系数（nSCV）比较，C组高于B组和A组，B组高于A组，差异均有统计学意义（均P ＜ 0.05），而三组24 h舒张压变异系数、日间舒张压变异系数、夜间舒张压变异系数比较，差异无统计学意义（P ＞ 0.05）。Pearson相关性分析显示：24 h SCV、dSCV、nSCV与BUA水平呈正相关（P ＜ 0.05）。结论社区原发性高血压患者BUA水平与收缩压变异性具有相关性，可作为提示高血压患者靶器官受损情况的参考指标。

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	靳丽娜1
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关键词 ：血尿酸, 高血压, 血压变异性

Abstract：Objective To study the relationship between serum uric acid (BUA) level and 24 hours blood pressure variability of hypertension patients in Jiaodong Community of Dongcheng District in Beijing, and find out its clinical significance. Methods The data of 126 hypertensive patients including levels of BUA, blood lipid, blood glucose in Jiaodong Community from January 2015 to December 2016 were collected and analyzed retrospectively. Patients were divided into 3 groups according to BUA levels: group A with 44 cases (BUA:250-<350 μmol/L), group B with 42 cases (BUA:350-<450 μmol/L), group C with 40 cases (BUA:450-550 μmol/L). The relationship between BUA and blood pressure variability was analyzed by Pearson analysis. Results The 24 h SCV, dSCV and nSCV were compared among the three groups, which in the group C were higher than those of group B and group A, which in the group B were higher than those of group A (all P ＜ 0.05); but there were no statistically significant differences in 24 h DCV, dDCV and nDCV among the three groups (P ＞ 0.05). Pearson correlation analysis showed that SCV, dSCV and nSCV were positively correlated with BUA (P ＜ 0.05). Conclusion In community, the hypertension patients′ BUA levels have correlated with systolic blood pressure variability, which can be taken as a reference index for prompting the target organ damage in the patients.

Key words： Serum uric acid Hypertension Blood pressure variability

引用本文:

靳丽娜1，2. 社区高血压患者血尿酸水平与24 h血压变异性的相关性研究[J]. 中国医药导报, 2017, 14(34): 54-57.
JIN Li′na1,2. Association between serum uric acid and 24 h blood pressure variability in community hypertension patients. 中国医药导报, 2017, 14(34): 54-57.

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