Abstract：M2 protein is a kind of membrane protein with ion channel activity in the envelop of influenza virus, which plays an important role in the life cycle of influenza virus. The N-terminal of the M2 protein is highly conserved, which is an important target for researching the universal vaccine. The transmembrane domain of M2 protein plays an important role in the progress of virus ribonucleoprotein complex entering into the nucleus, it is also the target for drug binding, but the appearance of drug-resistant mutants make the research of new drugs much more urgent. M2 protein also participates in the progress of virus budding, which is of great importance for the formation of virions. M2 protein can control the autophagy and apoptosis for the purpose of controlling the replication of virus through sophisticated mechanisms. This paper makes a review of M2 protein in the following aspects: vaccine research, proton conduction, drug research, assembly and budding, autophagy and apoptosis.
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2017, Vol. 14 
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