Influence factor analysis of ovarian metastasis in endometrial carcinoma
YANG Jing1 LEI Yuan1 XING Hui2
1.Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430000, China;
2.Department of Obstetrics and Gynecology, Affiliated Hospital of Hubei University of Arts and Science Xiangyang Central Hospital, Hubei Province, Xiangyang 441021, China
Abstract:Objective To study the influence factor of ovarian metastasis in endometrial carcinoma. Methods 310 cases of patients with endometrial carcinoma who were first diagnosed and operatively treated in Xiangyang Central Hospital from June 2010 to June 2016 were retrospectively analyzed. Results 30 cases (9.7%) had ovarian metastasis in 310 cases of endometrial carcinoma. Single factor analysis showed that pathological type, histological grade, depth of myometrial invasion, vaginal invasion, fallopian tubes metastasis, lymph node metastasis, peritoneal fluid cytology, CA125 were significantly associated with ovarian metastasis (P < 0.05), while age, menopause, cervical invasion were not significantly associated with ovarian metastasis (P > 0.05). Multiple factors analysis showed that, independent risk factors of ovarian metastasis included positive peritoneal fluid cytology, higher CA125 level, positive lymph node metastasis, histological grade G2-G3, non-adenocarcinoma, positive fallopian tubes metastasis (P < 0.05). Conclusion Positive peritoneal fluid cytology, higher CA125 level, positive lymph node metastasis, histological grade G2-G3, non-adenocarcinoma, positive fallopian tubes metastasis are the independent predictive factors of ovarian metastasis in endometrial carcinoma. Ovarian preservation in patients with endometrial carcinoma is feasible, however, multi-center and larger sample research is necessary.