Abstract：Paraoxonase-1 (PON1) is a high density lipoprotein-related esterase. PON1 plays an important physiological role in human serum. Its expression and activity are mainly affected by PON1 gene single nucleotide polymorphism. The relationship between single nucleotide polymorphism and disease is not consistent with individuals or populations. The occurrence of disease is the result of combination of genetical, physical and chemical factors. The relationship and mechanism between PON1 and many diseases remain unclear. This article aims to explore the relationship between PON1 and coronary heart disease, diabetes mellitus, stroke and cancer, and the possible pathogenesis, and provide new ideas for exploring the treatment and prevention of related diseases.
[1] Li Y，Liang G，Shi L，et al. Paraoxonase-1（PON1）rs662 polymorphism and its association with serum lipid levels and longevity in the Bama Zhuang population [J]. Med Sci Monit，2016，22：5154-5162.
[2] Sun T，Hu J，Yin Z，et al. Low serum paraoxonase1 activity levels predict coronary artery disease severity [J]. Oncotarget，2017，8：19443-19454.
[3] Shunmoogam N，Naidoo P，Chilton R. Paraoxonase （PON）-1：a brief overview on genetics，structure，polymorphisms and clinical relevance [J]. Vasc Health Risk Manag，2018，14：137-143.
[4] Goswami B，Tayal D，Gupta N，et al. Paraoxonase：a multifaceted biomolecule [J]. Clinica Chimica Acta，2009，410（1）：1-12.
[5] Mcdaniel CY，Dail MB，Wills RW，et al. Paraoxonase 1 polymorphisms within a mississippi usa population as possible biomarkers of enzyme activities associated with disease susceptibility [J]. Biochemical Genetics，2014， 52（11-12）：509-523.
[6] Mike M，Bharti M. Human paraoxonase-1 （PON1）：gene structure and expression，promiscuous activities and multiple physiological roles [J]. Gene，2015，567（1）：12-21.
[7] Bounafaa A，Berrougui H，Ghalim N，et al. Association between paraoxonase 1 （PON1） polymorphisms and the risk of acute coronary syndrome in a north African population [J]. PLoS One，2015，10（8）：e0133719.
[8] Cheraghi M，Shahsavari G，Maleki A，et al. Paraoxonase 1 activity，lipid profile，and atherogenic indexes status in coronary heart disease [J]. Rep Biochem Mol Biol，2017，6（1）：1-7.
[9] Deng Z，Xiang H，Gao W. Significant association between paraoxonase 1 rs662 polymorphism and coronary heart disease：a meta-analysis in the Chinese population [J]. Herz，2018.doi：10.1007/s00059-018-4737-8.
[10] Zhang Z，Ou Jk，Cai PL，et al. Association between the PON1 Q192R polymorphism and coronary heart disease in Chinese：a meta-analysis [J]. Medicine（Baltimore），2018，97（26）：e11151.
[11] Luo JQ，Ren HL，Mou Z，et al. European versus Asian differences for the associations between paraoxonase-1 genetic polymorphisms and susceptibility to type 2 diabetes mellitus [J]. J Cell Mol Med，2018，22：1720-1732.
[12] Salahshouri A，Alavijeh FZ，Mahaki B，et al. Effectiveness of educational intervention based on psychological factors on achieving health outcomes in patients with type 2 diabetes [J]. Diabetol Metab Syndr，2018，10：67.
[13] Lv M，Sun DJ，Chen LB. Identification of prognostic value of Rs3735590 polymorphism in 3′-untranslated region （3′-UTR） of Paraoxonase 1 （PON-1） in chronic obstructive pulmonary disease patients who received coronary artery bypass grafting [J]. Cell Physiol Biochem.，2018，47：1809-1818.
[14] Mahrooz A，Hashemi-Soteh MB，Heydari M，et al. Paraoxonase 1（PON1） -L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes [J]. Clin Chim Acta，2018，39（2）：102-112.
[15] Wamique M，Ali W，Reddy DH，et al. A case control study on HDL associated PON1 enzyme level in Northern Indian type 2 diabetes mellitus patients [J]. Diabetol Metab Syndr，2018，12（6）：843-847.
[16] Viktorinova A，Jurkovicova I，Fabryova L，et al. Abnormalities in the relationship of paraoxonase 1 with HDL and apolipoprotein A1 and their possible connection to HDL dysfunctionality in Type 2 diabetes [J]. Diabetes Res Clin Pract，2018，140：174-182.
[17] 霍然，宋宇，苏晓磊，等.脑卒中后脑网络重建及干细胞治疗[J].中华医学杂志，2018，98（29）：2360-2362.
[18] Wei LK，Au A，Menon S，et al. Polymorphisms of，MTHFR，eNOS，ACE，AGT，ApoE，PON1，PDE4Dand ischemic stroke：meta-analysis [J]. J Stroke Cerebrovasc Dis，2017， 26：2482-2493.
[19] Walsh KB，Hart K，Roll S，et al. Apolipoprotein AI and Paraoxonase-1 are potential blood biomarkers for ischemic stroke diagnosis [J]. J Stroke Cerebrovasc Dis，2016，25（6）：1360-1365.
[20] Li XQ，Ma N，Li XG，et al. Association of PON1，P2Y12 and COX1 with recurrent ischemic events in patients with extracranial or intracranial stenting [J]. PLoS One，2016，11（2）：e0148891.
[21] Kotur-Stevuljevic J，Bogavac-Stanojevic N，Jelic-Ivanovic Z，et al. Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients [J]. Atherosclerosis，2015， 241（1）：192-198.
[22] Wu J，Fang M，Zhou X，et al. Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women [J]. Oncotarget，2017，8（15）：25362-25371.
[23] Mustafa OK，Sinan S，Ozen OG，et al. Is there a relation between genetic susceptibility with cancer? a study about paraoxanase （PON1） enzyme activity in breast cancer cases [J]. J Enzyme Inhib Med Chem，2016，31（6）：1349-1355.
[24] Arenas M，Garcia-Heredia A，CabreN，et al. Effect of radiotherapy on activity and concentration of serum paraoxonase-1 in breast cancer patients [J]. PLoS One，2017， 12（11）：e0188633.
[25] Mbd A，Son YS，Sung HJ，et al. Paraoxonase-1 （PON1） induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells [J]. Oncotarget，2017，8（26）：42817-42835.
[26] Dowling P，Hayes C，Ting K，et al. Identification of proteins found to be significantly altered when comparing the serum proteome from multiple myeloma patients with varying degrees of bone disease [J]. BMC Genomics，2014， 15（1）：904.
2019, Vol. 16 
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