Abstract:Diabetic ulcer is one of the most serious complications of diabetes mellitus, but there is a lack of effective treatment and the cost of treatment is high. MicroRNAs (miRNAs) plays an important role in the healing process of diabetic ulcer. Through regulating the expression of target genes, regulating growth factors, cytokines, signal pathways and so on, thus affecting hemostasis and anti-inflammation. In this paper, the promotion and inhibition of miRNAs on diabetic ulcer healing are reviewed in order to provide new ideas for the treatment and curative effect evaluation of diabetic ulcer.
邢烨 袁娜 韩睿. MicroRNAs在糖尿病溃疡愈合中作用的研究进展[J]. 中国医药导报, 2019, 16(22): 58-61.
XING Ye YUAN Na HAN Rui. Progress in the role of MicroRNAs in the healing of diabetic ulcer. 中国医药导报, 2019, 16(22): 58-61.
[1] Zimmet PZ,Alberti KG. Epidemiology of diabetes-status of a pandemic and issues around metabolic surgery [J]. Diabetes Care,2016,39(6):878-883.
[2] Baltzis D,Eleftheriadou I. Pathogenesis and treatment of impaired wound healing in diabetes mellitus:new insights [J]. ADV Ther,2014,31(8):817-836.
[3] Davis FM,Kimball A. Dysfunctional wound healing in diabetic foot ulcers:new crossroads [J]. Curr Diab Rep,2018, 18(1):2.
[4] Fahs F,Bi XL. Small RNAs play big roles:microRNAs in diabetic wound healing [J]. Curr Mol Med,2016. [Epub ahead of print].
[5] Teruel-Montoya R,Rosendaal FR. MicroRNAs in hemostasis [J]. J Thromb Haemost,2015,13(2):170-181.
[6] Sunderland N,Skroblin P. MicroRNA biomarkers and platelet reactivity:the clot thickens [J]. Circ Res,2017,120(2):418-435.
[7] Moura LI,Cruz MT. The effect of neurotensin in human keratinocytes--implication on impaired wound healing in diabetes [J]. Exp Biol Med (Maywood),2014,239(1):6-12.
[8] Li X,Li D. MicroRNA-132 with therapeutic potential in chronic wounds [J]. J Invest Dermatol,2017,137(12):2630-2638.
[9] Li T,Ma Y. Platelet-rich plasma plays an antibacterial,anti-inflammatory and cell proliferation-promoting role in an in vitro model for diabetic infected wounds [J]. Infect Drug Resist,2019,12:297-309.
[10] Xu J,Wu W. The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment:correction with mesenchymal stem cell treatment [J]. Diabetes,2012,61(11):2906-2912.
[11] Shanmugam N,Reddy MA. Distinct roles of heterogeneous nuclear ribonuclear protein K and microRNA-16 in cyclooxygenase-2 RNA stability induced by S100b,a ligand of the receptor for advanced glycation end products [J]. J Biol Chem,2008,283(52):36221-36233.
[12] Li D,Wang A. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing [J]. J Clin Invest,2015,125(8):3008-3026.
[13] Tao SC,Guo SC. Chitosan wound dressings incorporating exosomes derived from microRNA-126-overexpressing synovium mesenchymal stem cells provide sustained release of exosomes and heal full thickness skin defects in a diabetic rat model [J]. Stem Cells Transl Med,2017,6(3):736-747.
[14] Icli B,Nabzdyk CS. Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a [J]. J Mol Cell Cardiol,2016,91:151-159.
[15] Wang JM,Tao J. MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus [J]. Arterioscler Thromb Vasc Biol,2014,34(1):99-109.
[16] Madhyastha R,Madhyastha H. MicroRNA signature in diabetic wound healing:promotive role of miR-21 in fibroblast migration [J]. Int Wound J,2012,9(4):355-361.
[17] Eming SA,Martin P. Wound repair and regeneration:mechanisms,signaling,and translation [J]. Sci Transl Med, 2014,6(265):265sr6.
[18] Xu J,Zgheib C. The role of microRNA-15b in the impaired angiogenesis in diabetic wounds [J]. Wound Repair Regen,2014,22(5):671-677.
[19] Honda N,Jinnin. TGF-β-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type Ⅰ collagen expression in scleroderma dermal fibroblasts [J]. J Immunol,2012,188(7):3323-3331.
[20] Caskey RC,Zgheib C. Dysregulation of collagen production in diabetes following recurrent skin injury:contribution to the development of a chronic wound [J]. Wound Repair Regen,2014,22(4):515-520.
[21] Ramirez HA,Pastar I. Staphylococcus aureus triggers induction of miR-15b-5p to diminish DNA repair and deregulate inflammatory response in diabetic foot ulcers [J]. J Invest Dermatol,2018,138(5):1187-1196.
[22] Ye J,Kang Y. MicroRNA-155 inhibition promoted wound healing in diabetic rats [J]. Int J Low Extrem Wounds,2017,16(2):74-84.
[23] Dangwal S,Stratmann B. Impairment of wound healing in patients with type 2 diabetes mellitus influences circulating microRNA patterns via inflammatory cytokines [J]. Arterioscler Thromb Vasc Biol,2015,35(6):1480-1488.
[24] Pizzino G,Irrera N. Effects of the antagomiRs 15b and 200b on the altered healing pattern of diabetic mice [J]. Br J Pharmacol,2018,175(4):644-655.
[25] Zhu L,Wang G. Suppression of microRNA-205-5p in human mesenchymal stem cells improves their therapeutic potential in treating diabetic foot disease [J]. Oncotarget,2017,8(32):52 294-52 303.
[26] Sundaram GM,Common JE. “See-saw” expression of microRNA-198 and FSTL1 from a single transcript in wound healing [J]. Nature,2013,495(7439):103-106.
[27] Lucas T,Schafer F. Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice [J]. Nat Commun,2017,8:15 162.
[28] Liu J,Xu Y. Quantification of the differential expression levels of microRNA-203 in different degrees of diabetic foot [J]. Int J Clin Exp Pathol,2015,8(10):13 416-13 420.
[29] Moura J,S?覬rensen A. MicroRNA-155 inhibition restores fibroblast growth factor 7 expression in diabetic skin and decreases wound inflammation [J]. Sci Rep,2019,9(1):5836.
[30] Ghai V,Wang K. Recent progress toward the use of circulating microRNAs as clinical biomarkers [J]. Arch Toxicol,2016,90(12):2959-2978.
[31] Zomer HD,Trentin AG. Skin wound healing in humans and mice:challenges in translational research [J]. J Dermatol Sci,2018,90(1):3-12.