血清miR-155联合HE4、CA199诊断子宫内膜癌的价值

摘要
图/表
参考文献(21)
相关文章 (13)

全文: PDF (608 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨血清miR-155联合人附睾蛋白4（HE4）、糖类抗原199（CA199）诊断子宫内膜癌（EC）的价值。方法选取2016年6月~2018年6月河北省邯郸市第一医院肿瘤科收治的68例EC患者为EC组，60例子宫内膜增生患者为内膜增生组，60名健康体检健康者为对照组。检测并比较三组血清miR-155、HE4、CA199水平，分析其对EC患者诊断价值。结果 EC组、内膜增生组患者血清miR-155、HE4、CA199水平均高于对照组（P < 0.05），且EC组高于内膜增生组（P < 0.05）；EC病理分级G3、G2级患者血清miR-155、HE4、CA199水平均高于G1级患者（P < 0.05），G3级患者高于G2级患者（P < 0.05）；EC FIGO分期Ⅱ、Ⅲ、Ⅳ期患者血清miR-155、HE4、CA199水平均高于Ⅰ期患者（P < 0.05），Ⅲ期、Ⅳ期患者高于Ⅱ期患者（P < 0.05），Ⅳ期患者高于Ⅲ期患者（P < 0.05）；绘制ROC曲线显示，三者联合检测的AUC、敏感性、特异性均高于单独检测。结论 EC患者血清miR-155、HE4、CA199均高表达，且随患者病理分级、FIGO分期升高而升高，三者联合诊断敏感性、特异性高，对EC患者早期诊断具有较高临床价值。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	陈玉芬1 韩敏1 张秀俊1 苏海飞2 张肖1

关键词 ：子宫内膜癌, miR-155, 人附睾蛋白4, 糖类抗原199, 诊断价值

Abstract：Objective To investigate the diagnostic values of serum miR-155 combined with human epididymal protein 4 (HE4) and carbohydrate antigen 199 (CA199) in endometrial cancer (EC). Methods Thirty-right patients with EC admitted to Oncology Department of Handan First Hospital in Hebei Province from June 2016 to June 2018 were selected as the EC group, 60 cases of endometrial hyperplasia patients were selected as the endometrial hyperplasia group, 60 healthy persons were taken as control group, the levels of serum microRNA-155, HE4 and CA199 were detected and compared among the three groups, and their diagnostic value for EC patients was analyzed. Results The levels of serum miR-155, HE4, and CA199 in EC group and endometrial hyperplasia group were higher than those in control group (P < 0.05), and those in EC group were higher than those in endometrial hyperplasia group (P < 0.05); the levels of serum miR-155, HE4, and CA199 in EC patients with pathological grades G3 and G2 were higher than those in patients with grade G1 (P < 0.05), while those in patients with grade G3 were higher than those in patients with grade G2 (P < 0.05); the levels of serum miR-155, HE4, and CA199 in EC patients with stage Ⅱ, Ⅲ, and Ⅳ of FIGO were higher than those in patients with stage Ⅲ (P < 0.05), those in patients with stage Ⅲ and Ⅳ were higher than those in patients with stage Ⅱ (P < 0.05), and those in patients with stage Ⅳ were higher than those in patients with stage Ⅲ (P < 0.05). The ROC curve showed that the AUC, sensitivity and specificity of the combined detection were higher than those of the single detection. Conclusion Serum miR-155, HE4, and CA199 are highly expressed in EC patients, and with the increases of pathological grade and FIGO stage, the sensitivity and specificity of the combined diagnosis are high, which has high clinical value for early diagnosis of EC patients.

Key words： Endometrial carcinoma MiR-155 Human epididymis protein 4 Carbohydrate antigen 199;

基金资助:河北省医学科学研究重点课题计划（20160332）。

作者简介: 陈玉芬（1975.5-），女，副主任医师；研究方向：子宫内膜癌的诊治。

引用本文:

陈玉芬1 韩敏1 张秀俊1 苏海飞2 张肖1. 血清miR-155联合HE4、CA199诊断子宫内膜癌的价值[J]. 中国医药导报, 2019, 16(20): 100-103.
CHEN Yufen1 HAN Min1 ZHANG Xiujun1 SU Haifei2 ZHANG Xiao1. Diagnostic values of serum MiR-155 combined with HE4 and CA199 in endometrial cancer. 中国医药导报, 2019, 16(20): 100-103.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I20/100

[1] Talhouk A，Hoang LN，Mcconechy MK，et al. Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy：earlier prognostic information to guide treatment [J]. Gynecol Oncol，2016，143（1）：46-53.
[2] Gibson WJ，Hoivik EA，Halle MK，et al. The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis [J]. Nat Genet，2016，48（8）：848-855.
[3] 陈丹丹，吴湖炳，王全师，等.18F-FDGPET/CT显像在子宫内膜癌术后复发及转移中的价值[J].中华核医学与分子影像杂志，2016，36（1）：39-43.
[4] 罗树玲，郑春艳，曹锦慧.血清CA125和HE4检测在子宫内膜癌中的临床意义[J].中国实验诊断学，2016，20（9）：1490-1492.
[5] 李姣玲，耿秀平，伍素卿，等.经阴道彩色多普勒超声联合血浆肿瘤标志物检测在子宫内膜癌诊断中的应用[J].中华医学超声杂志：电子版，2015，12（11）：894-900.
[6] 陈玉芬.子宫内膜癌患者血清中miR-155的表达及其临床意义研究[J].中国医药导刊，2015，16（1）：160-161.
[7] Ding K，Yuan Y，Chong QY，et al. Autocrine prolactin stimulates endometrial carcinoma growth and metastasis and reduces sensitivity to chemotherapy [J]. Endocrinology，2017，158（6）：1595-1611.
[8] 郑楠，谭文华.eIF4E及其在妇科恶性肿瘤中的研究进展[J].国际妇产科学杂志，2017，44（6）：667-670.
[9] 沈蓉，吴晓玲，肖子文，等.P-gp和GST-π在子宫内膜癌组织中的表达及与雌激素受体、孕激素受体的相关性[J].广东医学，2016，37（18）：2764-2767.
[10] 傅春江，毛廷森，曾泉，等.miR-155对人肝癌细胞系SK-HEP-1及MHCC-97H增殖与浸润能力的影响[J].生物技术通讯，2015，26（5）：600-604.
[11] Lerner C，Wemmert S，Bochen F，et al. Characterization of miR-146a and miR-155 in blood，tissue and cell lines of head and neck squamous cell carcinoma patients and their impact on cell proliferation and migration [J]. J Cancer Res Clin，2016，142（4）：757-766.
[12] Han JG，Jiang YD，Zhang CH，et al. A novel panel of serum miR-21/miR-155/miR-365 as a potential diagnostic biomarker for breast cancer [J]. Ann Surg Treat Res，2017， 92（2）：55-66.
[13] 周哲，蒋欣，宋继成，等.血清HE4、CP2检测对子宫内膜癌患者临床病理分子、肿瘤组织中增殖分子表达的评估价值[J].海南医学院学报，2016，22（13）：1410-1413.
[14] 李雪凤，闫雅妮，冯艳霞，等.经腹部和经阴道超声检查联合CA125+CA199辅助诊断子宫内膜癌的临床价值[J].中国妇幼保健，2017，32（9）：2024-2027.
[15] 唐霓，黄华仪，李惠清，等.不同年龄段成熟卵巢畸胎瘤患者CA125、CA199及肿瘤直径的临床研究[J].中国医学创新，2017，14（15）：48-50.
[16] Bian J，Sun XX，Li B，et al. Clinical significance of serum HE4，CA125，CA724 and CA19-9 in patients with endometrial cancer [J]. Technol Cancer Res T，2016，16（4）：435-439.
[17] Zhang XL，Chen JH，Qin CK. MicroRNA-155 expression as a prognostic factor in patients with gallbladder carcinoma after surgical resection [J]. Int J Clin Exp Med，2015， 8（11）：21 241-21 246.
[18] 张智，陈红霞，徐晓霞.血清人附睾蛋白E4、CA125、CA199联合诊断子宫内膜癌的价值[J].实用医学杂志，2016， 32（7）：1108-1111.
[19] Dolly D，Mihai A，Rimel BJ，et al. A delay from diagnosis to treatment is associated with a decreased overall survival for patients with endometrial cancer [J]. Front Oncol，2016，6（248）：31-35.
[20] 刘晓良，任健康.血清CA125与CA199联合检测在子宫内膜癌辅助诊断中的价值[J].西南国防医药，2016， 26（9）：1011-1013.
[21] Choi CH，Park YA，Choi JJ，et al. Angiotensin Ⅱ type Ⅰ receptor and miR-155 in endometrial cancers： synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells [J]. Gynecol Oncol，2015， 126（1）：124-131.