Research advances of adipose-derived stem cells on bone repair
ZHAO Daoyin1 NING Xu2 WANG Jian2
1.Guizhou Medical University, Guizhou Province, Guiyang 550004, China;
2.Department of Orthopedics, the Affiliated Hospital of Guizhou Medical University, Guizhou Province, Guiyang 550004, China
Abstract：Bone tissue engineering consists of three main factors: stem cells for osteogenesis, growth factors for bone induction and biodegradable scaffolds for bone conduction. Mesenchymal stem cells have achieved significant success in repairing bone defects, and their safety has been demonstrated in a number of preclinical trials. Adipose-derived stem cell (ADSCs) can also differentiate into osteoblasts, chondrocytes, myocytes and adipocytes, and they have similar differentiation potential to BMSCs with a minimally invasive approach. Meanwhile, their yield is also higher than BMSCs, which has a broad clinical application prospect.
赵道印1 宁旭2 汪健2. 脂肪来源干细胞骨修复研究进展[J]. 中国医药导报, 2019, 16(20): 49-52.
ZHAO Daoyin1 NING Xu2 WANG Jian2. Research advances of adipose-derived stem cells on bone repair. 中国医药导报, 2019, 16(20): 49-52.
[1] Park JS，Suryaprakash S，Lao YH，et al. Engineering mesenchymal stem cells for regenerative medicine and drug delivery [J]. Methods，2015，84：3-16.
[2] Bajek A，Olkowska J，Gurtowska N，et al. Human amniotic-fluid-derived stem cells： a unique source for regenerative medicine [J]. Expert Opin Biol Ther，2014，14（6）：831-839.
[3] Hernigou P，Trousselier M，Roubineau F，et al. Stem Cell Therapy for the Treatment of Hip Osteonecrosis： A 30-Year Review of Progress [J]. Clin Orthop Surg，2016，8（1）：1-8.
[4] Li Q，Wang T，Zhang GF，et al. A comparative evaluation of the mechanical properties of two calcium phosphate/collagen composite materials and their osteogenic effects on adipose-derived stem cells [J]. Stem Cells Int，2016， 2016：1-12.
[5] de Girolamo L，Sartori MF，Albisetti W，et al. Osteogenic differentiation of human adipose-derived stem cells：comparison of two different inductive media [J]. J Tissue Eng Regen Med，2007，1（2）：154-157.
[6] Wang ZL，He RZ，Tu B，et al. Drilling combined with adipose-derived stem cells and bone morphogenetic protein-2 to treat femoral head epiphyseal Necrosis in Juvenile rabbits [J]. Curr Med Sci，2018，38（2）：277-288.
[7] Zhu Z，Yuan Z，Huang C，et al. Pre-culture of adipose-derived stem cells and heterologous acellular dermal matrix： paracrine functions promote post-implantation neovascularization and attenuate inflammatory response [J]. Biomed Mater，2019，14（3）：035002.
[8] Tajima S，Tobita M，Orbay H，et al. Direct and indirect effects of a combination of adipose-derived stem cells and platelet-rich plasma on bone regeneration [J]. Tissue Eng （Part A），2015，21（5/6）：895-905.
[9] Li B，Wang H，Qiu G，et al. Synergistic effects of vascular endothelial growth factor on bone morphogenetic proteins induced bone formation in vivo：influencing factors and future research directions [J]. Biomed Res Int，2016，2016：2869572.
[10] 高洁，王明国，杨帅，等.不同生长因子对脂肪干细胞生物学行为的影响[J].中国组织工程研究，2015，19（19）： 3010-3016.
[11] Wen YH，Lin WY，Lin CJ，et al. Sustained or higher levels of growth factors in platelet-rich plasma during 7-day storage [J]. Clin Chim Acta，2018，483：89-93.
[12] Dhurat R，Sukesh M. Principles and methods of preparation of platelet-rich plasma： a review and author′s perspective [J]. J Cutan Aesthet Surg，2014，7（4）：189-197.
[13] Chen CF，Liao HT. Platelet-rich plasma enhances adipose-derived stem cell-mediated angiogenesis in a mouse ischemic hindlimb model [J]. World J Stem Cells，2018，10（12）：212-227.
[14] Cvetkovi■ VJ，Najdanovi■ JG，Vukeli■-Nikoli■ M■，et al. Osteogenic potential of in vitro osteo-induced adipose-derived mesenchymal stem cells combined with platelet-rich plasma in an ectopic model [J]. Int Orthop，2015，39（11）：2173-2180.
[15] Shafieian R，Matin MM，Rahpeyma A，et al. Effects of human adipose-derived stem cells and platelet-rich plasma on healing response of canine alveolar surgical bone defects [J]. Arch Bone Jt Surg，2017，5（6）： 406-418.
[16] 胡育瑄，何家才.不同方法制备富血小板血浆对兔脂肪干细胞增殖和成骨分化能力的影响[J].安徽医科大学学报，2018，53（8）：1184-1190.
[17] 孙仕晨，董腾哲，黄昕，等.Transwell共培养条件下诱导脂肪干细胞成骨能力的改变[J].中国组织工程研究，2016， 20（28）：4155-4161.
[18] 杨民，郑伟伟，林程.骨髓间质干细胞和脂肪间质干细胞混合培养后的成骨能力[J].中华骨科杂志，2016，36（23）：1524-1532.
[19] Kang ML，Kim JE，Im GI. Vascular endothelial growth factor-transfected adipose-derived stromal cells enhance bone regeneration and neovascularization from bone marrow stromal cells [J]. J Tissue Eng Regen Med，2017，11（12）：3337-3348.
[20] Zhao X，Liu L，Wang FK，et al. Coculture of vascular endothelial cells and adipose-derived stem cells as a source for bone engineering [J]. Ann Plast Surg，2012，69（1）：91-98.
[21] Souza DC，Abreu HLV，Oliveira PV，et al. A fast degrading PLLA composite with a high content of functionalized octacalcium phosphate mineral phase induces stem cells differentiation [J]. J Mech Behav Biomed Mater，2019， 93：93-104.
[22] Fang J，Li P，Lu X，et al. A strong，tough，and osteoconductive hydroxyapatite mineralized polyacrylamide/dextran hydrogel for bone tissue regeneration [J]. Acta Biomater，2019，88：503-513.
[23] de Girolamo L，Arrigoni E，Stanco D，et al. Role of autologous rabbit adipose-derived stem cells in the early phases of the repairing process of critical bone defects [J]. J Orthop Res，2011，29（1）：100-108.
[24] Thesleff T，Lehtim?覿ki K，Niskakangas T，et al. Cranioplasty with adipose-derived stem cells and biomaterial： a novel method for cranial reconstruction [J]. Neurosurgery，2011， 68（6）：1535-1540.
[25] Van Esterik FA，Zandieh-Doulabi B，Kleverlaan CJ，et al. Enhanced osteogenic and vasculogenic differentiation potential of human adipose stem cells on biphasic calcium phosphate scaffolds in fibrin gels [J]. Stem Cells Int，2016，2016：1934270.
[26] 王腾飞，宋兴华，麦麦提艾力·阿不力克木，等.脂肪干细胞与羟基磷灰石/β-磷酸三钙复合体修复兔椎体缺损[J].中国组织工程研究，2018，22（13）：2081-2086.
[27] 龙志成，宋兴华，龙仕杰，等.脂肪干细胞复合HA/β-TCP与同种异体骨修复兔脊柱骨缺损的比较[J].中国矫形外科杂志，2018，26（2）：164-169.
[28] 唐宇星，赵庆，杨中萌，等.聚乳酸共聚物复合脂肪干细胞对骨质疏松性骨折愈后生物力学的影响[J].中国组织工程研究，2017，21（10）：1577-1582.
[29] Park H，Kim JS，Oh EJ，et al. Effects of three-dimensionally printed polycaprolactone/β-tricalcium phosphate scaffold on osteogenic differentiation of adipose tissue- and bone marrow-derived stem cells[J].Arch Craniofac Surg，2018，19（3）：181-189.
[30] Lee MK，DeConde AS，Lee M，et al. Biomimetic scaffolds facilitate healing of critical-sized segmental mandibular defects [J]. Am J Otolaryngol，2015，36（1）：1-6.
[31] 宋杨，王晓飞，王宇光，等.人脂肪间充质干细胞与生物材料共混物三维打印体的体内成骨[J].北京大学学报：医学版，2016，48（1）：45-50.
[32] Kang HW，Lee SJ，Ko IK，et al. A 3D bioprinting system to produce human-scale tissue constructs with structural integrity [J]. Nat Biotechnol，2016，34（3）：312-319.
[33] Lendeckel S，J?觟dicke A，Christophis P，et al. Autologous stem cells （adipose） and fibrin glue used to treat widespread traumatic calvarial defects： case report [J]. J Craniomaxillofac Surg，2004，32（6）：370-373.
[34] Sándor GK，Tuovinen VJ，Wolff J，et al. Adipose stem cell tissue-engineered construct used to treat large anterior mandibular defect： a case report and review of the clinical application of good manufacturing practice-level adipose stem cells for bone regeneration [J]. J Oral Maxillofac Surg，2013，71（5）：938-950.
[35] Dufrane D，Docquier PL，Delloye C，et al. Scaffold-free three-dimensional graft from autologous adipose-derived stem cells for large bone defect reconstruction： clinical proof of concept [J]. Medicine （Baltimore），2015，94（50）：1-10.
[36] Mesim?覿ki K，Lindroos B，T?觟rnwall J，et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells [J]. Int J Oral Maxillofac Surg，2009， 38（3）：201-209.
[37] 郭恩琪，谢庆平，朱孜冠，等.严重复合组织缺损皮瓣修复术后应用自体脂肪干细胞构建组织工程骨重建骨支架[J].中华显微外科杂志，2017，40（3）：213-217.
2019, Vol. 16 
京公网安备 11010502046598号