Abstract：Objective To compare the difference between antral follicle count (AFC), anti Mullerian hormone (AMH) and sex hormone in predicting ovarian function. Methods From January 2014 to December 2015, in Reproductive Center, Cangzhou People's Hospital, 284 female infertility patients received in vitro fertilization and embryo transfer (IVF-ET) treatment were selected as the research object, according to the number of oocytes, they were divided into groups of poor ovarian response group (193 cases) and normal ovarian response group (91 cases). Before treatment by transvaginal ultrasound, the diameter 3-10 mm AFC number were calculated, on the third day of menstrual blood test AMH and basal hormone levels (FSH, LH, E2, FSH/LH ratio), the sensitivity and specificity of AFC, AMH and sex hormone in the evaluation of ovarian reserve function were analyzed. Results AMH and AFC of poor ovarian response group were less than the normal ovarian response group, FSH and E2 value of poor ovarian response group was higher than the normal ovarian response group, FSH/LH value of poor ovarian response group was more than the normal ovarian response group, the differences were statistically significant (P < 0.05). The sensitivity and specificity of AMH projecting poor ovarian response were 0.91 and 0.72, the sensitivity and specificity of AFC were 0.88 and 0.93, the sensitivity and specificity of FSH/LH were 0.78 and 0.72, these were higher than the levels of single basal sex hormones. Conclusion The sensitivity and specificity of AFC, AMH and FSH/LH predicting ovarian reserve function are stronger than those of single hormone FSH, LH and E2.
韩晓霞 左瑞菊 马肖. 窦卵泡计数、抗苗勒管激素与性激素检测评价卵巢储备的研究[J]. 中国医药导报, 2017, 14(18): 117-120.
HAN Xiaoxia ZUO Ruiju MA Xiao. Research of ovarian reserve by counting the number of antral follicle count, anti Mullerian hormone and sex hormone. 中国医药导报, 2017, 14(18): 117-120.
[1] Visser JA，de Jong FH，Laven JS，et al. Anti-Müllerian hormone：a new marker for ovarian function [J]. Reproduction.2006，131（1）：1-9.
[2] Weenen C，Laven JS，Von Bergh AR，wt al. Anti-Müllerian hormone expression pattern in the human ovary：potential implications for initial and cyclic follicle recruitment [J]. Mol Hum Reprod，2004，10（2）：77-83.
[3] Van Disseldorp J，Lambalk CB，Kwee J，et al. Comparison of inter-and intra-cycle variability of anti-Mullerian hormone and antral follicle counts [J]. Hum Reprod，2010，25（1）：221-227.
[4] Hansen KR，Hodnett GM，Knowlton N，et al. Correlation of ovarian reserve tests with histologically determined primordial follicle number [J]. Fertil Steril，2011，95（1）：170-175.
[5] La Marca A，Stabile G，Artenisio AC，et al. Serum anti-Mullerian hormone throughout the human menstrual cycle [J]. Hum Reprod，2006，21（12）：3103-3107.
[6] 李莹，杨晓庆，杨小葵.抗苗勒管激素和抑制素B预测卵巢储备功能的临床研究[J].实用妇产科杂志，2014，30（1）：26-28.
[7] 石洁，张云山.抗苗勒管激素、抑制素B及超声预测卵巢储备功能[J].国际生殖健康/计划生育杂志，2009，28（1）：96-98.
[8] Eldar-Geva T，Ben-Chetrit A，Spitz IM，et al. Dynamic assays of inhibin B，anti-Mullerian hormone and estradiol following FSH stimulation and ovarian ultrasonography as predictors of IVF outcome [J]. Hum Reprod，2005，20（11）：3178-3183.
[9] La Marca A，Giulini S，Tirelli A，et al. Anti-Müllerian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology [J]. Hum Reprod，2007，22（3）：766-771.
[10] Pigny P，Jonard S，Robert Y，et al. Serum anti-Mullerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome [J]. Clin Endocrinol Metab，2006，91（3）：941-945.
[11] Muttukrishna S，Suharjono H，McGarrigle H，et al .Inhibin B and anti-Mullerian hormone： markers of ovarian response in IVF/ICSI patients?[J]. BJOG，2004，111（11）：1248-1253.
[12] Fanchin R，Mendez Lozano DH，Frydman N，et al. Anti-Müllerian hormone concentrations in the follicular fluid of the preovulatory follicle are predictive of the implantation potential of the ensuing embryo obtained by in vitro fertilization [J]. Clin Endocrinol Metab，2007，92（5）：1796-1802.
[13] Bancsi LF，Broekmans FJ，Eijkemans MJ，et al. Predictors of poor ovarian response in in vitro fertilization：a prospective study comparing basal markers of ovarian reserve [J]. Fertil Steril，2002，7（2）：328-336.
[14] Haadsma ML，Bukman A，Groen H，et al. The number of small antral follicles （2-6 mm） determines the outcome of endocrine ovarian reserve tests in a subfertile population [J]. Hum Reprod，2007，22（7）：1925-1931.
[15] 王丹瑾，马成斌，糜茵.基础FSH/LH在预测年轻不孕女性卵巢储备功能及自然周期排卵率中的价值[J].检验医学与临床，2016，14（1）：124-126.
[16] Broekmans FJ，de Ziegler D，Howles CM，et al. The antral follicle count： practical recommendations for better standardization [J]. Fertil Steril，2010，94（3）：1044-1051.
[17] Jirge PR. Ovarian reserve tests [J]. Hum Reprod Sci，2011，4（3）：108-113.
[18] 陈玲抗苗勒管激素对卵巢功能的调节及预测作用[J].医学综述，2013，19（8）：802-803.
[19] Weghofer A，Feichtinger W. The forgotten variable：impact of luteinizing hormone on the prediction of ovarian reserve [J]. Fertil Steril，2006，85（1）：259-261.
[20] Honnma H，Asada Y，Baba T，et al. Continuous high-dose estrogen controls serum FSH and LH levels：new treatment strategy for extremely low ovarian reserve patients，two case reports [J]. Gynecol Endocrinol，2014，30（5）：341-344.
[21] 吴惠华，李红，孟庆霞，等.年轻妇女卵泡刺激素/黄体生成素比值预测卵巢储备功能及体外受精-胚胎移植的结局[J].生殖医学杂志，2013，22（2）：101-105.
[22] Noci I，Biagiotti R，Maggi M，et al. Low day 3 luteinizing hormone values are predictive of reduced response to ovarian stimulation [J]. Hum Reprod，1998 ，13（3）：531-534.
2017, Vol. 14 
京公网安备 11010502046598号