Change of interleukin-17 levels in both synovial fluid and plasm of patients with primary knee osteoarthritis accompanied by meniscus injuries after arthroscopic surgery
ZHANG Haisen1 BAI Yuming1 LIU Chang1 JIN Shengli1 SU Ke1 LIU Ying2 LYU Zhichang3
1.The Sencod Derpatment of Orthopaedics Surgery, Central Hospital of Cangzhou, Hebei Province, Cangzhou 061001, China;
2.Operating Room, People′s Hospital of Cangzhou, Hebei Province, Cangzhou 061001, China;
3.Derpatment of Orthopaedics Surgery, People′s Hospital of Xian County, Hebei Province, Xianxian 062250, China
Abstract：Objective To investigate interleukin-17 (IL-17) levels in both synovial fluid and plasm of patients with primary knee medial osteoarthritis (OA) accompanied by medial meniscus injuries after arthroscopic surgery. Methods 46 patients with primary knee OA accompanied by medial meniscus injuries underwent arthroscopic surgery in Central Hospital of Cangzhou from January 2014 to June 2015 were selected as the experimental group, and 30 healthy individuals were selected as the control group. Visual analog scale (VAS) pain score and Lysholm score were used to evaluate the pain level and function of the knees of patients with OA. The IL-17 concentrations in both plasma and synovial fluid of patients were measured at preoperative period and postoperative 3, 6, 12 months, and in plasma of controls were determined using auantitative sandwich enzyme-linked immunoassay. Results Postoperative incisions were Ⅰ stage healing for patients. All patients were followed up for 12-18 months, average of 15 months. Postoperative VAS pain scores significantly decreased and Lysholm scores significantly increased compared with preoperative periods (P < 0.05). For VAS scores and Lysholm scores, there were no statistically significant differences between postoperative points (P > 0.05). Patients before arthroscopic surgery had higher plasma IL-17 concentrations compared to control group (P < 0.05). Average postoperative IL-17 levels in plasma at each time point of patients were significant lower than preoperative periods (P < 0.05), but higher than control group (P < 0.05). Postoperative plasm and synovial fluid IL-17 levels of patients after the surgery had no statistically significant differences among postoperative points (P > 0.05). Conclusion Arthroscopic surgery can significantly improve the pain symptoms and joint function and reduce IL-17 levels in both synovial fluid and plasm of the patients with knee OA accompanied by medial meniscus injuries, but IL-17 can not back to healthy level.
张海森1 白玉明1 刘畅1 靳胜利1 苏珂1 刘颖2 吕志昌3. 伴有半月板损伤的膝骨关节炎患者采用关节镜治疗术后白介素-17的水平变化[J]. 中国医药导报, 2017, 14(18): 87-90.
ZHANG Haisen1 BAI Yuming1 LIU Chang1 JIN Shengli1 SU Ke1 LIU Ying2 LYU Zhichang3. Change of interleukin-17 levels in both synovial fluid and plasm of patients with primary knee osteoarthritis accompanied by meniscus injuries after arthroscopic surgery. 中国医药导报, 2017, 14(18): 87-90.
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2017, Vol. 14 
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