ApoE基因敲除小鼠疾病模型的研究进展
宋珂1 侯彦宏2 杨会3 白云绮1 李慧3 聂波1
1.北京中医药大学东直门医院中医内科学教育部重点实验室和北京市重点实验室,北京 100700;
2.中国中医科学院中医药发展研究中心,北京 100700;
3.北京中医药大学中药学院,北京 100029
Advances in research on disease model of ApoE knockout mice
SONG Ke1 HOU Yanhong2 YANG Hui3 BAI Yunqi1 LI Hui3 NIE Bo1
1.Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Key Laboratory, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
2.Research Center for Chinese Medicine Development, China Academy of Chinese Medical Sciences, Beijing 100700, China;
3.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
摘要 载脂蛋白E(ApoE)是一种有明显基因多态性、多功能蛋白,与脂蛋白的代谢有密切联系,其缺失和变异都会引起体内代谢失常及功能紊乱,甚至引起一系列疾病和并发症。近年来,ApoE-/-小鼠主要应用于动脉粥样硬化、糖尿病、神经退化性疾病、肾脏病等。为了更好地研究ApoE在各疾病模型中的应用机制,为临床疾病治疗提供更加有力的依据,本文总结了人类ApoE基因型与ApoE蛋白相关的几种疾病的发生机制,并对体外研究疾病发展过程的动物模型进行了综述。
关键词 :
载脂蛋白E ,
基因敲除 ,
动物模型 ,
研究进展
Abstract :Apolipoprotein E (ApoE) is a kind of gene polymorphism and multifunctional protein, which is closely related to the metabolism of lipoprotein. Its deletions and mutations can cause metabolic disorders and dysfunction in the body, and even cause a series of diseases and complications. In recent years, ApoE-/- mice have been mainly used in atherosclerosis, diabetes, neurodegenerative diseases and kidney diseases. In order to better study the application mechanism of ApoE in various disease models and provide a more powerful basis for clinical treatment of diseases, this paper summarizes the pathogenesis of several diseases related to ApoE protein in human ApoE genotype, and summarizes the animal models for in vitro study of disease development process.
Key words :
Apolipoprotein E
Gene knockout
Animal model
Research progress
基金资助: 国家自然科学基金青年基金项目(81403365);
国家自然科学基金面上项目(81874446)。
通讯作者:
聂波(1977.12-),女,博士,研究员;研究方向:中医药防治动脉粥样硬化及其作用机制。
作者简介 : 宋珂(1994.9-),女,硕士;研究方向:中西医结合心血管病。
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